On January 4, 2019 C4 Therapeutics (C4T) reported the transformation of its ongoing research and development partnership with Roche focusing on new cancer treatments based on C4T’s targeted protein degradation technology (Press release, C4 Therapeutics, JAN 4, 2019, View Source [SID1234532465]).

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"We are excited to see our partnership with Roche evolve and further accelerate our efforts to bring degrader-based medicines into the clinic," said Andrew Phillips, PhD, President and CEO of C4 Therapeutics. "Roche has been a valued and excellent partner since we started our collaboration in 2016. This transformed partnership reflects how much both parties believe in the potential of degraders as a new treatment modality for patients."

Under the terms of the expansion, C4T will lead efforts from discovery through defined preclinical or early clinical milestones, depending on the program. Upon C4T reaching these milestone events, Roche will have exclusive options for worldwide rights to continue development and commercialize drugs from these programs. In addition, C4T will have the option to co-develop and co-promote in the U.S. on selected programs. C4T will receive a significant upfront payment and near-term preclinical milestones. Upon success C4T may also receive royalties and potential clinical, regulatory, and commercial milestone payments totaling over $900 million.

On January 4, 2019 Diffusion Pharmaceuticals Inc. (Nasdaq: DFFN), a cutting-edge biotechnology company developing new treatments for life-threatening medical conditions by improving the body’s ability to bring oxygen to the areas where it’s needed most, reported that Chief Executive Officer David Kalergis will join investors, executives, civic leaders, and scientists to present at the 37th Annual J.P. Morgan Healthcare Conference on Monday, January 7, 2019 at 7:00pm EST/4:00pm PST (Press release, Diffusion Pharmaceuticals, JAN 4, 2019, View Source [SID1234532482]). The Conference will be held on January 7-10, 2019 at the Westin St. Francis Hotel in San Francisco, California.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"Advancements in the biotechnology, pharmaceutical, and medical industries don’t happen in a vacuum; they require collaboration between investors, scientists, and business leaders," said David Kalergis, Chairman and CEO of Diffusion. "Diffusion was founded in that same spirit of collaboration, and at the 37th Annual J.P. Morgan Healthcare Conference, we’ll have the opportunity to share our progress with an even larger audience of leaders who can potentially work with us to fuel life and fight deadly conditions such as cancer and stroke."

The "largest and most informative healthcare investment symposium in the industry," the J.P. Morgan Healthcare Conference brings together "industry leaders, emerging fast-growth companies, innovative technology creators, and members of the investment community." Over 9,000 attendees and representatives from over 450 public and private companies have had the chance at past conferences to hear from speakers including Bill Gates, Vice President Joe Biden, and CEO of 23andMe Anne Wojcicki. To listen to Mr. Kalergis’s presentation live, you can go to the Investor Relations section of the Diffusion Pharmaceuticals website at www.diffusionpharma.com. An archived webcast of the presentation will also be available on the Company’s website for a period of time.

On January 4, 2019 Atara Biotherapeutics, Inc. (Nasdaq:ATRA), a leading off-the-shelf, allogeneic T-cell immunotherapy company developing novel treatments for patients with cancer, autoimmune and viral diseases, reported that Isaac Ciechanover, M.D., the Company’s President and Chief Executive Officer, will present at the 37th Annual J.P. Morgan Healthcare Conference on Tuesday, January 8, 2019 at 10:30 a.m. Pacific Standard Time (Press release, Atara Biotherapeutics, JAN 4, 2019, View Source [SID1234532447]). The conference will be held at the Westin St. Francis in San Francisco, California.

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A live audio webcast of the presentation will be available by visiting the Investors and Media section of the Atara website. An archived replay of the webcast will be available on the Company’s website for 14 days following the live presentation.

On January 4, 2019 Relay Therapeutics, a new breed of company at the intersection of computation and biotechnology, reported that Sanjiv Patel, M.D., president and chief executive officer, is scheduled to present an overview of the company’s business and scientific objectives at the 37th Annual J.P. Morgan Healthcare Conference in San Francisco on Thursday, January 10, 2019 at 11:00 a.m. PT (2:00 p.m. ET) (Press release, Relay Therapeutics, JAN 4, 2019, View Source [SID1234532466]).

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On January 4, 2019 PierianDx, a leading clinical genomics informatics company, reported a strategic, non-exclusive, multi-year partnership with Illumina, Inc. to provide a variant interpretation and reporting solution based on PierianDx’s Clinical Genomics Workspace platform and Clinical Genomics Knowledgebase for select Illumina oncology products (Press release, PierianDx, JAN 4, 2019, View Source [SID1234554038]). Under the agreement, PierianDx and Illumina will offer customers the option of informatics capabilities for Illumina oncology products, including Illumina’s TruSight Tumor 170 and TruSight Oncology 500, which are currently intended for research use only (RUO). The partnership extends to support Illumina’s future oncology in vitro diagnostic (IVD) offerings. Advancing cancer diagnostics and making targeted therapeutics more accessible to healthcare systems, laboratories, and patients worldwide is a key focus of both parties.

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"Accessibility of genomic testing in clinical oncology is critical to realizing the promise of immuno- and targeted therapies and personalized medicine," states Rakesh Nagarajan, MD, PhD, Founder and Executive Chairman, PierianDx. "Today, few laboratories have the ability to offer comprehensive tumor profiling because of the complexities associated with validating large NGS assays and interpreting genomic results. This agreement between PierianDx and Illumina has the potential to provide laboratories clinically-optimized solutions that may accelerate assay validation and deployment and simplify genomic interpretation."

"The combination of Illumina’s comprehensive tumor profiling assays with Pierian Dx’s variant interpretation and reporting solutions will provide customers with a seamless experience," said Garret Hampton, PhD, Executive Vice President of Clinical Genomics at Illumina.

"PierianDx is thrilled to receive this substantial validation of our genomics Software as a Service (‘SaaS’) platform by a global leader in our space. Our relationship with Illumina will allow us to greatly accelerate our U.S. and international strategic plans as we seek to be the wisdom behind every genomics report," said Michael L. Sanderson, CEO of PierianDx.

Under the agreement Illumina and its affiliates will be responsible for the distribution of the RUO oncology products and packaged solutions. Laboratories that purchase the RUO products from Illumina will have an option to receive from PierianDx standardized reporting, driven by professional guidelines for streamlined case review and sign-out. In addition, laboratories who purchase the bundled RUO oncology product with the PierianDx informatics solution will receive access to PierianDx’s Clinical Genomics Workspace for analysis, interpretation, and reporting of genomic results. Laboratories will also have the opportunity to engage PierianDx for additional services such as genomic interpretation, medical sign-out, and electronic medical record integration.