On January 3, 2019 Personal Genome Diagnostics Inc. (PGDx), a leader in cancer genomics, reported that its 500+ gene pan-cancer tumor profiling tissue assay is being used in Merck’s Phase 2 precision oncology KeyImPaCT study of biomarker-directed, pembrolizumab-based combination therapy for advanced non-small-cell lung cancer (NSCLC) (KEYNOTE-495) (Press release, Personal Genome Diagnostics, JAN 3, 2019, View Source [SID1234532419]). This study will investigate the utility of biomarker-based triage for study participants with previously untreated advanced NSCLC. The PGDx elioTM tissue complete assay is being used during the enrollment process for the analysis of tumor mutational burden (TMB) status.

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Study participants within groups defined by a biomarker-based classifier (gene expression profile [GEP] and TMB) will be randomized to receive pembrolizumab in combination with MK-4280 or lenvatinib. The study will involve more than 70 clinical sites worldwide.

"We are proud to collaborate with Merck on this trial. Merck is a leader in immune oncology and we view their selection of PGDx as a testament to our capabilities around TMB," said Doug Ward, Chief Executive Officer at PGDx. "With the kitted approach for the PGDx elio portfolio, we aim to expand patient access to comprehensive, local genomic testing and reduce turn-around time for results that inform critical treatment decisions for patients worldwide."

PGDx provides genomic solutions from biomarker discovery to companion diagnostic development through its CAP/CLIA certified laboratory and is developing a portfolio of regulated tissue-based and liquid biopsy genomic products to enable local next-generation sequencing (NGS) testing in laboratories worldwide.

On January 3, 2019 Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE), a biopharmaceutical company focused on the development of novel products for serious rare and ultra-rare genetic diseases, reported that Emil D. Kakkis, M.D., Ph.D., the company’s Chief Executive Officer and President, will present at the 37TH Annual J.P. Morgan Healthcare Conference on Tuesday, January 8, 2019 at 4:00 pm PT in San Francisco (Press release, Ultragenyx Pharmaceutical, JAN 3, 2019, View Source [SID1234532435]).

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The live and archived webcast of the company presentations will be accessible from the company’s website at View Source The replay of the webcast will be available for 90 days.

On January 3, 2019 Aduro Biotech, Inc. (NASDAQ: ADRO) reported that Stephen T. Isaacs, chairman, president and chief executive officer of Aduro, is scheduled to present at the 37TH Annual J.P. Morgan Healthcare Conference in San Francisco, California on Thursday, January 10, 2019 at 11:30 am PST (Press release, Aduro Biotech, JAN 3, 2019, View Source;p=RssLanding&cat=news&id=2381999 [SID1234532455]).

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To access the live webcast and subsequent archived recording of this and other company presentations, please visit the investor section of Aduro’s website at www.aduro.com. The archived webcast will remain available for replay on Aduro’s website for 30 days.

On January 3, 2019 Kiadis Pharma N.V. ("Kiadis Pharma" or the "Company") (Euronext Amsterdam and Brussels: KDS), a clinical-stage biopharmaceutical company, reported that it is scheduled to present at the Biotech Showcase(TM) 2019 at the Hilton San Francisco Union Square in January 2019 (Press release, Kiadis, JAN 3, 2019, View Source [SID1234533320]).

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Biotech Showcase 2019
January 7-9, 2019
Hilton San Francisco Union Square Hotel, 333 O’Farrell Street, San Francisco, CA
Hilton/Yosemite A, Ballroom Level
Arthur Lahr, CEO, will present on Monday, January 7 at 3:30pm PST.

The Kiadis management team will also host one-on-one meetings from January 7-10 in San Francisco

On January 3, 2019 Integral Molecular, the industry leader in the discovery of monoclonal antibodies (MAbs) against multipass membrane proteins, and Ono Pharmaceutical Co., Ltd. reported that they have entered into a new collaboration for antibody discovery following a previously successful collaboration (Press release, Integral Molecular, JAN 3, 2019, View Source [SID1234533986]). This second collaboration involves the discovery of candidate MAbs against an undisclosed target and leverages the power of Integral Molecular’s MPS Antibody Discovery platform.

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Integral Molecular has used the MPS platform to discover antibody assets targeting a number of other multipass membrane proteins, including GPCRs (CB1) and transporters (GLUT4). Many of these MAbs are the first of their kind to be isolated, as complex membrane proteins have historically been extremely difficult targets for antibody discovery.

"We have a proven track record discovering large panels of high-affinity antibodies against difficult membrane proteins. This has been driven by our innovative MPS platform and over 15 years of experience working with multipass membrane proteins, so we are confident in the success of this collaboration," said Dr. Ross Chambers, VP of Antibody Discovery at Integral Molecular. "We are pleased that Ono, a global leader in innovative medicines, considers us to be a trusted partner in antibody discovery."

"We have been impressed by Integral Molecular’s membrane protein expertise and their proven record in discovering antibodies against them," said Hideaki Tada, Executive Director, Center of Oncology Research of Ono. "This is our second collaboration with Integral Molecular, and we are very pleased to deepen our engagement with them."