On October 1, 2018 Pulse Biosciences, Inc. (NASDAQ: PLSE), a novel medical therapy company bringing to market its proprietary Nano-Pulse Stimulation platform, reported that Darrin Uecker, President and Chief Executive Officer, is scheduled to present at the Cantor Global Healthcare Conference in New York at 4:00 p.m. Eastern Time on Wednesday, October 3rd, 2018 (Press release, Pulse Biosciences, OCT 1, 2018, View Source [SID1234529694]).

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A live webcast of the presentation will be available through the Investor Relations pages of the Pulse Biosciences website at View Source and at View Source Following the live presentation, the webcast will be archived and available for replay at the same address for a period of 90 days.

On October 1, 2018 Hitachi Chemical Advanced Therapeutics Solutions, LLC (HCATS) reported that they have signed a three-year clinical manufacturing agreement with GSK, a science-led global healthcare company (Press release, HCATS, OCT 1, 2018, https://www.businesswire.com/news/home/20181001005013/en/Hitachi-Chemical-Advanced-Therapeutics-Solutions-Signs-Three-Year [SID1234529696]). Under the agreement, HCATS will manufacture GSK’s SPEAR T-cell receptor therapy targeting NY-ESO-1 for the US, Canadian and European trials. NY-ESO is expressed across a variety of tumors including sarcomas, melanoma, multiple myeloma, bladder cancer, non-small cell lung cancer, ovarian cancer and gastro-intestinal cancers.

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HCATS is a US subsidiary of Hitachi Chemical Co. Ltd. that engages in contract manufacturing and development of cell-based cell and gene therapy products through its PCT Global Service Platform.

"Since becoming part of Hitachi Chemical over a year ago, we have seen increasing interest in leveraging our PCT Global Service Platform both in the United States and Japan," said Robert A. Preti, PhD, CEO and President of HCATS and General Manager of the Hitachi Chemical Regenerative Medicine Business Sector. "This agreement is an exciting step for our growing global enterprise, advancing our vision to support efforts to make these transformative therapies accessible to all."

"We are extremely proud and grateful to enter into a relationship with GSK, as it provides the opportunity to partner with an industry leader," said Sanjin Zvonić, PhD, Senior Director, Business Leader, Clinical and Commercial Manufacturing of HCATS. "As with all our clients, we are committed to delivering high-quality, compliant, flexible, scalable, and cost-effective manufacturing services."

On October 1, 2018 Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical company developing personalized cancer immunotherapies, reported two additions to its leadership team: Thomas Davis, M.D. as Chief Medical Officer and Derek Meisner, J.D. as General Counsel (Press release, Genocea Biosciences, OCT 1, 2018, View Source [SID1234529854]).

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"We continue to advance our lead cancer vaccine, GEN-009 and expand the applications for our novel and proprietary ATLAS platform to demonstrate what we believe are critical advantages in neoantigen identification," said Chip Clark, President & CEO of Genocea. "We believe our emerging pipeline of novel neoantigen vaccine and cell therapy programs holds significant promise, and we believe this promise is the reason we’ve been able to attract such talent to Genocea. Tom and Derek bring a depth of industry expertise and quality of insight that will be invaluable."

Dr. Davis joins Genocea with 20+ years of academic and industry experience in immuno-oncology and cancer drug development. Dr. Davis previously served as Chief Medical Officer of Gadeta B.V., a Dutch cell therapy company pursuing novel cancer targets, where he steered a novel cell therapy technology into first-in human clinical studies. He also previously served as Chief Medical Officer of Celldex, a cancer vaccine company, where he led all aspects of clinical and regulatory development.

Mr. Meisner brings broad legal expertise to Genocea as its first in-house General Counsel. He has extensive experience as a corporate attorney, previously serving as the General Counsel to multiple Boston-based financial services firms, including life science investor RA Capital, as well as serving as Partner at the international law firm K&L Gates and as Branch Chief in the Division of Enforcement of the U.S. Securities and Exchange Commission.

On October 1, 2018 DCprime reported that Jeroen Rovers MD, PhD joins the company as its Chief Medical Officer with immediate effect (Press release, DCPrime, OCT 1, 2018, View Source [SID1234531233]). Jeroen trained as a pharmaceutical physician at the European Center of Pharmaceutical Medicine in Basel . In the past 15 years he worked in different academic institutes and companies, lastly at Kiadis Pharma where he in his role of Chief Medical Officer was part of the management team that took the company public on Euronext Amsterdam in 2015. Most of the products he worked on are related to specialized therapeutic areas, such as oncology, haematology and transplantation.

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Jeroen Rovers comments: "It is an exciting time to join DCprime, as it’s products are moving further into clinical development. Cell based vaccins will potentially be an additional asset in the immunotherapeutic arsenal to prevent or reduce recurrence of cancer and to improve the of life of people living with cancer."

Erik Manting, CEO of DCprime adds: "The appointment of Jeroen Rovers as Chief Medical Officer marks an important step in the development of DCprime as a company. We are transitioning from a technology-driven company to an organisation focused on achieving clinical results. We have launched an international PhII trial in AML with our lead product DCP-001 and aim to launch additional clinical trials in other cancer types in 2019. With Jeroen on board as an experienced CMO we will further strengthen our infrastructure and capabilities to bring cancer immunotherapeutics to clinic."

On October 1, 2018 Exicure, Inc. (OTCQB:XCUR), the pioneer in gene regulatory and immunotherapeutic drugs utilizing three-dimensional, spherical nucleic acid (SNA) constructs, repoted its presented data in a poster session on Sunday, September 30 at the 4th CRI-CIMT-EATI-AACR International Immunotherapy Conference: Translating Science into Survival in New York, New York (Press release, Exicure, OCT 1, 2018, View Source;p=RssLanding&cat=news&id=2369523 [SID1234529700]).

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The poster titled "AST-008, a novel TLR9 agonist SNA, induces abscopal antitumor effects in mouse tumor models" supports the ongoing clinical development of the Company’s proprietary SNA technology and highlights new data showing the effects of Exicure’s technology on mouse tumor models through a systemic immune response.

These data presented in the poster session show that both subcutaneous and intra-tumoral administration of AST-008 into one tumor lesion in the mouse model leads to systemic antitumor activity at a distant, un-injected tumor.

"These new data, along with data from other pre-clinical tumor model studies in combination with an anti-PD-1 antibody, and our recently completed Phase 1 trial support the continued advancement of Exicure’s drug candidate AST-008," said Dr. David Giljohann, Chief Executive Officer of Exicure. "We intend to launch our Phase 1b/2 clinical trial in combination with a checkpoint inhibitor in Q4 of 2018."