On September 6, 2018 Advaxis, Inc. (Nasdaq: ADXS) ("Advaxis" or the "Company") reported that it intends to offer and sell in an underwritten public offering shares of its common stock, with each share of common stock to be sold together in a fixed combination with a warrant to purchase common stock (Press release, Advaxis, SEP 6, 2018, View Source [SID1234530400]). The offering is subject to market conditions and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Cantor Fitzgerald & Co. and Oppenheimer & Co. Inc. are acting as joint book-running managers for the offering.

The Company intends to use the net proceeds of the offering to fund its continued research and development initiatives in connection with expanding its product pipeline and for other general corporate purposes, including, but not limited to (i) progression of ADXS-HOT into clinical research in both monotherapy and combination therapy; (ii) investment in ongoing clinical research in ADXS-PSA and ADXS-NEO, both in monotherapy and combination therapy; and (iii) investment in ongoing clinical research with axalimogene filolisbac in head and neck cancer and other HPV associated cancers, including any wind down costs associated with ongoing trials.

The securities described above will be offered by the Company pursuant to a "shelf" registration statement (File No. 333-226988) previously filed with the Securities and Exchange Commission (the "SEC") on August 23, 2018 and declared effective by the SEC on August 30, 2018.

The offering may be made only by means of a prospectus supplement and the accompanying prospectus. Before investing in the offering, you should read in their entirety the prospectus supplement and the accompanying prospectus and the other documents that Advaxis has filed with the SEC that are incorporated by reference in the prospectus supplement and the accompanying prospectus, which provide more information about the Company and the offering. A preliminary prospectus supplement and the accompanying prospectus related to the offering will be filed with the SEC and will be available on the SEC’s website at View Source, copies of which can be obtained, when available, from Cantor Fitzgerald & Co., Attention: Capital Markets, 499 Park Ave., 6th Floor, New York, New York 10022, or by email at [email protected], or from Oppenheimer & Co. Inc., Attention: Syndicate Prospectus Department, 85 Broad Street, 26th Floor, New York, New York 10004, by telephone at 212-667-8055, or by email at [email protected].

This press release shall not constitute an offer to sell, or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On September 6, 2018 Bristol-Myers Squibb Company (NYSE:BMY) reported that it will announce results for the third quarter of 2018 on Thursday, October 25, 2018. During a conference call at 10:30 a.m. EDT on October 25, company executives will review financial information and will address inquiries from investors and analysts (Press release, Bristol-Myers Squibb, SEP 6, 2018, View Source [SID1234529331]).

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Investors and the general public are invited to listen to a live webcast of the call at View Source or by dialing in the U.S. toll free 866-548-4713 or international 323-794-2093, confirmation code: 3801700. Materials related to the call will be available at the same website prior to the conference call. A replay of the call will be available beginning at 1:45 p.m. EDT on October 25 through 1:45 p.m. EDT on November 8, 2018. The replay will also be available through View Source or by dialing in the U.S. toll free 888-203-1112 or international 719-457-0820, confirmation code: 3801700.

On September 6, 2018 Pfizer Inc. reported its invites investors and the general public to listen to a webcast of a discussion with Frank D’Amelio, Executive Vice President, Business Operations, and Chief Financial Officer, at the Morgan Stanley 16th Annual Global Healthcare Conference on Thursday, September 13, 2018 at 2:55 p.m. Eastern Daylight Time (Press release, Pfizer, SEP 6, 2018, View Source [SID1234529428]).

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To listen to the webcast, visit our web site at www.pfizer.com/investors. Information on accessing and pre -registering for the webcast will be available at www.pfizer.com/investors beginning today.

Visitors will be able to listen to an archived copy of the webcast at www.pfizer.com/investors.

On September 6, 2018 Gibson Oncology, LLC ("Gibson"), a privately held clinical stage company, reported that it acquired three (3) clinical non-camptothecin Topoisomerase I drugs from Linus Oncology (Press release, Gibson Oncology, SEP 6, 2018, View Source [SID1234532070]). These novel anti-cancer drugs have been tested in over 70 patients by the National Cancer Institute (NCI) and have been shown to be both safe and effective in phase I clinical trials. There are multiple United States and international patents on these agents.

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The compounds acquired are indenoisoquinolines ("indenos"), a novel class of drugs which were invented and developed by Purdue University and the NCI to minimize the diarrhea and neutropenia associated with the administration of traditional camptothecin agents such as irinotecan and topotecan. The multiple phase I trials have shown effectiveness in end-stage cancer patients with solid tumors who had failed administration of up to nine (9) drugs given previously. Simultaneously, these new drugs dramatically reduce the incidence of grade 3 and 4 neutropenia and diarrhea.

In addition, Gibson strengthened its Indeno product platform through obtaining an exclusive, worldwide development and commercialization license from Purdue University for the recently discovered pro-drugs for this novel class of compounds.

With pre-clinical studies already performed which demonstrate both the effectiveness of indenos after the development of irinotecan resistance as well as synergy between PARP inhibitors and the indenos, Gibson intends to approach the FDA about phase II studies. Several academic organizations, both in the United States and in Europe, have approached Gibson about helping conduct these studies.

"We are excited to advance these novel, potent, and well-tolerated small molecule topoisomerase I inhibitor drugs in advanced stage and/or resistant cancers as a single agent or in combination with immune-oncology and targeted therapies for improved patient outcomes," stated Randall Riggs, CEO of Gibson Oncology, LLC.

On September 6, 2018 Twentyeight-Seven Therapeutics (28-7), a biotechnology company focused on modulating non-coding RNA (ncRNA) biology to develop treatments for cancer and other diseases, reported the successful completion of its $65 million Series A financing (Press release, Twentyeight-Seven Therapeutics, SEPT 6, 2018, View Source [SID1234529351]). Founding investor MPM Capital and Novartis Venture Fund co-led the financing. They were joined by additional investors including Johnson & Johnson Innovation – JJDC, Inc., Vertex Ventures HC, Longwood Fund, and Astellas Venture Management. The funding will be used to advance 28-7’s lead program, aimed at the discovery and development of small molecules that increase the levels of the tumor suppressor microRNA (miRNA), Let-7, into serious cancer indications.

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"This strong financing round was achieved thanks to the new biological understanding and impressive scientific data around non-coding RNA produced by our four scientific founders and the progress the 28-7 team has made since it was founded two years ago," said Kazumi Shiosaki, Ph.D., founding President and Chief Executive Officer, 28-7. "Our experienced investors realize the promise in this new field of therapeutics and in the robust leads produced by our founders, who have made many of the seminal discoveries in this field, and by the exceptional scientists within the company."

In addition, 28-7 announced that Shomir Ghosh, Ph.D., has joined as its Chief Scientific Officer. Most recently CSO and a founding scientist at IFM Therapeutics, Dr. Ghosh has 25 years of scientific research, drug discovery and development experience in biotech and large pharma, and has successfully delivered multiple compounds into preclinical and clinical development in the immunology, oncology and CNS therapeutic areas.

"I am incredibly excited to join 28-7 and support the advancement of its lead program," said Dr. Ghosh. "I look forward to working with Kazumi and our accomplished team and Board as we discover new ways to fight cancer and grow our operations."

28-7’s initial focus is on modulating miRNAs, which are short ncRNAs that inhibit target gene expression by suppressing mRNA translation and/or promoting mRNA decay. It is now well recognized that miRNAs are directly involved in cancer initiation, progression, and metastasis. 28-7’s technology does not focus on directly targeting the RNA itself or on developing oligonucleotides, but rather targets RNA modulating proteins (RMPs), enabling the use of small molecule drug candidates with broader access to cells and tissues. Let-7 is an miRNA that suppresses the translation of oncogenes in cells, and low levels of this miRNA are correlated with greater cancer aggressiveness. The company’s leading protein target is Lin28, an RMP that reduces the levels of Let-7, and has been shown to be an oncogene, promoting cellular transformation and tumorigenesis. 28-7 is developing first-in-class drugs that inhibit Lin28’s activity and thus raise levels of Let-7 for treatment of various cancers.

The company’s core technology comes from its four founding scientists, all leading researchers in RNA biology and cancer:

George Daley, M.D., Ph.D. ─ Dean of the Faculty of Medicine and Professor of Medicine, Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Richard Gregory, Ph.D. ─ Professor of Biological Chemistry and Molecular Pharmacology, and Pediatrics, Harvard Medical School
Frank Slack, Ph.D. ─ Professor of Pathology, Harvard Medical School, Professor of Pathology and Director of Institute of RNA Medicine, Beth Israel Deaconess Medical Center
Piotr Sliz, Ph.D. ─ Associate Professor of Pediatrics and of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
This founding group has been collaborating for years and has made substantial contributions to the science of ncRNA biology, including elucidating the role of ncRNAs in disease and identifying new RMP targets for drug discovery programs.

"Our founders have made important scientific contributions to the field of ncRNA biology, including the discovery of the Lin28/Let-7 pathway and its role in normal development, metabolism, and malignancy. Overall, our studies have established Lin28/Let-7 as a major regulatory pathway in stem cells and cancer," said George Daley, M.D., Ph.D., 28-7’s co-founder and Chairman of the company’s Scientific Advisory Board, and Dean and Professor of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School. "We felt that the time was right to move these insights from the laboratory to pharmaceutical development, and we are very pleased by the progress the company achieved in the first two years of its existence. With this impressive round of funding and our continued support, 28-7 will unlock the therapeutic potential of our work."

In addition to Dr. Shiosaki, several investors will join 28-7’s Board of Directors, including:

· Luke Evnin, Ph.D. ─ Managing Director and co-founder, MPM Capital

· Briggs Morrison, M.D. ─ Executive Partner, MPM Capital and CEO of Syndax Pharmaceuticals, Inc.

· Carolyn Ng, Ph.D. ─ Principal, Vertex Ventures HC

· Michal Silverberg, M.B.A. ─ Managing Director, Novartis Venture Fund