On May 24, 2018 Glactone Pharma reported that in strong competition and after external examination, the company in collaboration with researchers from Karolinska Institutet and Lund University has been awarded a SEK 1,000,000 (approx. USD 115,000) grant from Swelife and Medtech4health, two Swedish national life-science innovation programs funded by Vinnova, Sweden’s Innovation Agency (Press release, Glactone Pharma, MAY 24, 2018, View Source [SID1234526882]). Glactone Pharma’s funded project, STAT3 inhibition as immunotherapy for the treatment of prostate cancer, aims to investigate the mechanism behind the combination effect of STAT3 inhibition and immunotherapy. Unravelling the mechanism is an important step in the development towards an effective immunotherapy for prostate cancer. The call for applications was aimed towards projects that have a strong innovation potential and that address unmet medical needs and demands from patients, caregivers and healthcare systems.

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Glactone Pharma is a Swedish biotech company developing novel drugs that can inhibit the transcription factor STAT3, a highly relevant drug target in cancer. The project is a collaboration with Dr Andreas Lundqvist, Associate Professor, Karolinska Institutet, Department of Oncology-Pathology and Professor Anders Bjartell, Department of Translational Medicine, Medical Faculty, Lund University. Glactone Pharma will provide expertise in drug development as well as access to the company’s candidate drug. The groups of Dr Lundqvist and Professor Bjartell will provide expertise in the areas of tumor immunology and prostate cancer respectively.

The objective for this project is to investigate the mechanism that links STAT3 inhibition to increased efficacy of checkpoint inhibition immunotherapy in prostate cancer. Using advanced models of prostate cancer, the interactions between immune cells and prostate cancer cells following STAT3 inhibition will be studied. Having this information is very important in order to predict which patients might respond and to guide the optimal treatment, thereby increasing the chances of success in future clinical trials.

Martin Johansson, CEO of Glactone Pharma, says: "Immunotherapy is one of the most exciting and promising areas of drug development today. However, many limitations exist. With the funding for this project, we can address a great unmet medical need and potentially bring forward an innovative and effective treatment for prostate cancer patients. We are very grateful to be recognized in this way and we look forward to collaborating with two leading Swedish academic institutions."

About immunotherapy
Immunotherapy is a treatment modality that activates and utilizes the body’s own immune system to recognize and attack tumors and is today the fastest growing and most promising area of cancer research. With the great potential that immunotherapies offer for cancer patients, a large interest in novel immunotherapies has arisen.

About STAT3
STAT3 (Signal Transducer and Activator of Transcription 3) is a transcription factor/signaling protein that is frequently activated in many forms of cancer.

STAT3 is a highly promising target in cancer with both preclinical and clinical data supporting the important roles that STAT3 plays in cancer occurrence and progression. In particular, STAT3 is involved in mechanisms that enable tumors and cancer cells to evade the immune system and become treatment resistant.

STAT3 is an intractable drug target as it is an intracellular protein with no enzymatic activity and is activated by multiple upstream factors. Despite STAT3 not being a "classic drug target", Glactone Pharma has developed orally bioavailable small molecule inhibitors that can directly inhibit the function of STAT3.

On May 23, 2018 Onxeo S.A. (Euronext Paris, NASDAQ Copenhagen: ONXEO FR0010095596), a biotechnology company specializing in the development of innovative drugs in oncology, notably against rare or resistant forms of cancer, reported that Judith Greciet, the Company’s Chief Executive Officer, will present at the 25th BIO International Convention (Press release, Onxeo, MAY 23, 2018, View Source [SID1234526866]). The conference is being held on June 4-7, 2018, in Boston, MA.

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The BIO International Convention is hosted by the Biotechnology Innovation Organization (BIO). It is attended by more than 1,100 biotechnology and pharmaceutical companies, academic institutions, state biotechnology centers and related organizations across the United States and from over 30 countries worldwide.

Onxeo corporate presentation:

Date: June 4th, 2018

Time: 3 pm EST / 9 pm CEST

Location: Theater 2 – Boston Convention & Exhibition Center: 415 Summer St., Boston, MA

180523_ONXEO_PR_EN_BIO

On May 23, 2018 Celyad (Euronext Brussels and Paris, and NASDAQ: CYAD), a clinical-stage biopharmaceutical company focused on the development of specialized CAR-T cell based therapies, reported the closing of a global offering of 2,070,000 ordinary shares to purchasers in the United States, Europe and certain countries outside the United States and Europe, comprised of 568,500 ordinary shares in the form of American Depositary Shares (ADSs) at a price per ADS of $26.28, and 1,501,500 ordinary shares at a price per share of € 22.29 (the "global offering") (Press release, Celyad, MAY 23, 2018, View Source [SID1234532515]). Each ADS represents the right to receive one ordinary share. The number of ADSs and ordinary shares sold in the global offering reflects the full exercise of the underwriters’ option to purchase additional shares.

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The gross proceeds to Celyad from the global offering amounted to approximately $54.4 million (approximately €46.1 million), before deducting underwriting commissions and estimated offering expenses.

Celyad’s ADSs are currently listed on the NASDAQ Global Market under the symbol "CYAD" and Celyad’s ordinary shares are currently listed on Euronext Brussels and Euronext Paris.

Wells Fargo Securities, LLC and Bryan, Garnier & Co. acted as joint bookrunning managers for the offering. Bank Degroof Petercam NV acted as a co-manager for the private placement and LifeSci Capital LLC acted as a co-manager for the global offering. Kempen & Co NV was Celyad’s advisor in connection with the offering. No stabilization activity was undertaken in connection with the global offering.

The securities were offered pursuant to an effective shelf registration statement that was previously filed with, and declared effective by, the U.S. Securities and Exchange Commission (SEC). A final prospectus supplement dated May 17, 2018 relating to and describing the terms of the offering was filed with the SEC on May 18, 2018 and is available on the SEC’s website at www.sec.gov. Copies of the final prospectus supplement and the accompanying prospectus relating to these securities can be obtained for free from Wells Fargo Securities, LLC, Attention: Equity Syndicate Department, 375 Park Avenue, New York, New York, 10152, at (800) 326-5897 or email a request to [email protected] or Bryan, Garnier & Co., Beaufort House, 15 Saint Botolph Street, London EC3A 7BB, United Kingdom, or by telephone at +44 20 7332 2500, or by email at [email protected].

This press release does not constitute an offer to sell nor a solicitation of an offer to buy, nor shall there be any sale of securities in any state or jurisdiction in which such an offer, solicitation or sale is or would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On May 23, 2018 mAbxience, a company specialized in the research, development, manufacturing and global commercialization of monoclonal antibody biosimilars -part of the Insud Pharma Group- and Amneal Pharmaceuticals, Inc., an integrated specialty pharmaceutical company powered by a robust U.S. generics business, have signed an exclusive licensing and supply agreement in the United States for mAbxience´s bevacizumab, a biosimilar candidate for Avastin (Press release, mAbxience, MAY 23, 2018, View Source [SID1234611988]).

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Under the milestone based commercial agreement mAbxience will lead product, clinical development and subsequent manufacture while Amneal will guide the product through regulatory approval and have exclusive commercialisation rights in the United States.

"We are very proud to deepen our partnership with Amneal with the bevacizumab biosimilar agreement. We are passionate about increasing access and affordability of biologics in all countries around the world and this latest agreement with Amneal will be an important contribution to public health in the United States," said Emmanuelle Lepine, General Manager of mAbxience.

mAbxience is progressing its international expansion, and recently established partnerships in Europe and Australia for its bevacizumab biosimilar. Building long lasting partnerships is central to the company´s business philosophy. Biosimilars bring patients a safe, effective, efficient and affordable treatment option, which contributes to the sustainability of healthcare systems worldwide. More than 10,000 patients have now been treated with a mAbxience biosimilar.

On May 23, 2018 Varian (NYSE: VAR) reported that Gary Bischoping, chief financial officer, and J. Michael Bruff, senior vice president of investor relations, will present at the Jefferies Global Healthcare Conference in New York City, scheduled for 11:30 a.m. ET on June 6, 2018 (Press release, Varian Medical Systems, MAY 23, 2018, View Source [SID1234526868]).

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Information about the webcast of the company’s presentation will be available through a link on the company website at www.varian.com/inv­estors.