On March 18, 2024 Carina Biotech Limited (Carina), a clinical stage cell therapy immuno-oncology company, reported three poster presentations from studies of its LGR5-targeting CAR-T program in colorectal cancer and ovarian cancer at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2024 that will take place in San Diego, California, on April 5-10 (Press release, Carina Biotech, MAR 18, 2024, View Source;utm_medium=rss&utm_campaign=press-release-carina-to-present-three-poster-presentations-at-aacr-annual-meeting-2024 [SID1234641257]).
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"We are looking forward to sharing data related to our LRG-5 targeted CAR-T program in three poster presentations at the upcoming AACR (Free AACR Whitepaper) annual meeting. One of the posters will highlight the GMP manufacturing and testing findings for our lead LGR5-targeted CAR-T cell therapy candidate CNA3103, that is currently being evaluated in a Phase 1/2 clinical trial for the treatment of adult patients with metastatic colorectal cancer," stated Deborah Rathjen, PhD, Carina’s Chief Executive Officer.
"Our research team will also be presenting preclinical data that demonstrate the potential to develop our LGR5-targeting CAR-T cells as a novel immunotherapy for ovarian cancer and that expand the preclinical body of evidence across a diverse range of cancer families, including ovarian, brain, liver, and stomach, where LGR5-targeting CAR-T cells may be harnessed."
Poster Presentation Details
Title: Preclinical in vivo characterization underpinning LGR5-targeting CAR-T cells as a cancer immunotherapy
Lead Author: Jade Foeng, PhD, Chemokine Biology Laboratory, Department of Molecular and Biomedical Science, The University of Adelaide, South Australia
Session Category: Immunology
Session Title: Adoptive Cell Therapies: CAR-T Cells
Session Date and Time: Sunday, April 7, 2024 1:30 pm PT – 5:00 pm PT
Location: Poster Section 2
Poster Board Number: 24
Published Abstract Number: 56
Title: CAR-T cells targeting LGR5: An effective treatment for chemotherapy resistant ovarian cancer
Lead Author: Wanqi (Jady) Wang, Robinson Research Institute, The University of Adelaide, South Australia
Session Category: Clinical Research
Session Title: Adoptive Cell Therapy 2
Session Date and Time: Tuesday, April 9, 2024 1:30 pm PT – 5:00 pm PT
Location: Poster Section 40
Poster Board Number: 11
Published Abstract Number: 6320
Title: From bench to bedside: GMP manufacturing and testing of LGR5-targeting CAR-T against colorectal cancer
Lead Author: Veronika Bandara, PhD, Molecular Immunology Laboratory, Robinson Research Institute, The University of Adelaide, South Australia
Session Category: Clinical Research
Session Title: Adoptive Cell Therapy 2
Session Date and Time: Tuesday, April 9, 2024 1:30 pm PT – 5:00 pm PT
Location: Poster Section 40
Poster Board Number: 22
Published Abstract Number: 6311