On October 1, 2021 Candel Therapeutics, Inc. (Nasdaq: CADL), a late clinical stage biopharmaceutical company developing novel oncolytic viral immunotherapies, reported that its President and Chief Executive Officer, Paul Peter Tak, MD, PhD, FMedSci, and E. Antonio Chiocca, MD, PhD, FAANS, an investigator on Candel’s clinical trials in brain cancer, will present data and overviews pertaining to oncolytic viral immunotherapies for glioblastoma and other solid tumors at the following upcoming scientific conferences (Press release, Candel Therapeutics, OCT 1, 2021, View Source [SID1234590650]).
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Cambridge Healthtech Institute’s 9th Annual Immuno-Oncology Summit Conference Program: Oncolytic Virus Immunotherapy
Date and Time: Wednesday, Oct. 6, 2021
Presenter: Paul Peter Tak, MD, PhD, FMedSci
Presentation Title: Novel Oncolytic Viral Immunotherapies for Solid Tumors
Hanson Wade’s 6th Annual Oncolytic Virotherapy Summit
Date and Time: Wednesday, Oct. 27, 2021
Presenter: Paul Peter Tak, MD, PhD, FMedSci
Presentation Title: Novel Oncolytic Viral Immunotherapies to Immunize Against the Patient’s Own Tumor Neo-antigens: CAN-2409 and CAN-3110
Hanson Wade’s 6th Annual Oncolytic Virotherapy Summit
Date and Time: Wednesday, Oct. 27, 2021
Presenter: E. Antonio Chiocca, MD, PhD, FAANS
Presentation Title: Improving Oncolytic HSV1 for Glioblastoma Therapy
Details from the presentations will be available on the Candel website at View Source
About CAN-2409
CAN-2409, Candel’s most advanced oncolytic viral immunotherapy candidate, is a replication-deficient adenovirus that delivers the herpes simplex virus thymidine kinase (HSV-tk) gene to cancer cells. HSV-tk is an enzyme that locally converts orally administered valacyclovir into a toxic metabolite that kills nearby cancer cells. The intra-tumoral administration results in the local release of tumor-specific neo-antigens. At the same time, the adenoviral serotype 5 capsid protein elicits a strong pro-inflammatory signal in the tumor microenvironment. This creates the optimal conditions to induce a CD8+ T cell mediated response against the injected tumor and uninjected distant metastases for broad anti-tumor activity.
Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. Monotherapy activity as well as combination activity with standard of care radiotherapy, surgery, chemotherapy, and immune checkpoint inhibitors have previously been shown in several preclinical and clinical settings. Furthermore, CAN-2409 presents a favorable tolerability profile; more than 700 patients have been dosed to date, supporting the potential for combination with other therapeutic strategies without inordinate concern of overlapping adverse events. Currently, Candel is evaluating the effects of treatment with CAN-2409 in localized, non-metastatic prostate cancer, non-small cell lung cancer, high-grade glioma, and pancreatic cancer in ongoing clinical trials.
About CAN-3110
CAN-3110 is an HSV replication-competent oncolytic virus engineered to enhance selective killing of cancer cells while sparing neighboring healthy cells. CAN-3110 selectively expresses ICP34.5, a key gene in HSV replication, in tumor cells that overexpress nestin, a cytoskeletal protein. Nestin is highly expressed in high-grade glioma cells and other tumor tissues, but it is absent in the healthy adult brain.
Candel is evaluating the effects of treatment with CAN-3110 in recurrent high-grade glioma. Encouraging clinical results of the ongoing phase 1 clinical trial were recently presented at the 2021 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting.