On April 9, 2024 Calidi Biotherapeutics Inc. (NYSE American: CLDI) ("Calidi"), a clinical-stage biotechnology company developing a new generation of targeted immunotherapies, reported the presentation of new data detailing the molecular mechanisms of action underlying the immunomodulatory role of Calidi’s therapies at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual (AACR) (Free AACR Whitepaper) Meeting 2024, in San Diego, California (Press release, Calidi Biotherapeutics, APR 9, 2024, View Source [SID1234641969]). The poster, titled "Deciphering anticancer mechanisms of oncolytic virus-loaded stem cells," will be presented on April 9, 2024, during the Chemotherapy, Radiation, and Vaccine Mediated Immunity session.
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"Calidi’s novel approach to treating cancer has always centered around the stem cell as a means of protecting, delivering, and potentiating our tumor-killing virotherapeutic payloads. We believe this novel approach using allogeneic stem cells differentiates our technology and offers the potential of our platforms, CLD-101 and CLD-201, to serve as universal, off-the-shelf, options for patients needing improved therapeutic outcomes in their treatments for cancer," said Allan Camaisa, CEO and Chairman of the Board at Calidi Biotherapeutics.
"The data presented at AACR (Free AACR Whitepaper), in close collaboration with our long-standing partners at City of Hope, describes how stem cells may improve anticancer actions of oncolytic viruses, by not only protecting and potentiating virotherapy, but by secreting immunomodulatory molecules into the tumor microenvironment. We are excited to continue research in the field of oncology by better understanding the mechanism of action for Calidi’s lead assets, and their potential treatment for solid tumors," said Antonio F. Santidrian, Chief Scientific Officer of Calidi Biotherapeutics.
Antitumor virotherapies are capable of selectively eradicating tumor cells without endangering healthy cells in the body. Viruses that enter the body are immediately inactivated by the immune system. Calidi is developing two platforms, CLD-101 and CLD-201, that consist of oncolytic viruses loaded into stem cells, designed to cloak the tumor-killing viruses from the immune system. In the studies presented at AACR (Free AACR Whitepaper), scientists at Calidi Biotherapeutics and City of Hope researched the stem cells secretome transcriptomic of CLD-101 and CLD-201. The transcriptomic analysis showed that immunomodulatory cytokines, and chemokines, are induced following oncolytic virus infection demonstrating a potential immunotherapeutic role of the cells, in addition to the delivery and protection of the oncolytic viruses. Together these findings suggest that the enhanced antitumor actions of Calidi’s therapies are partially due to the alterations in the stem cells’ secretome, reinforcing the potential of the company’s novel approach to treat solid tumors.
Calidi previously announced that its partner, City of Hope, dosed the first patient in a Phase 1 clinical trial evaluating CLD-101 in recurrent high-grade glioma patients. The company expects to report a clinical update in the second quarter of 2024. A previously completed Phase 1 dose escalation clinical trial showed CLD-101 was well-tolerated and demonstrated stimulation of an antitumor immune response. The company expects to start clinical trials with CLD-201 by the end of 2024, subject to the company’s continued ability to raise the capital necessary to fund its clinical development programs.
This poster will be posted to the "Scientific Publications" section of the Calidi Biotherapeutics website following the conclusion of the conference.