On May 29, 2024 BostonGene, a leading provider of AI-driven molecular and immune profiling solutions, reported that seven abstracts have been accepted for the 2024 ASCO (Free ASCO Whitepaper) Annual Meeting (ASCO) (Free ASCO Whitepaper), scheduled to take place May 31 – June 3, 2024, at McCormick Place Convention Center in Chicago, IL (Press release, BostonGene, MAY 29, 2024, View Source [SID1234643826]). BostonGene will deliver one oral presentation and present two posters, while four abstract presentations will be available online. BostonGene will also exhibit at booth 22157.
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At the event, BostonGene will feature its AI-powered multiomics platform that rapidly accelerates new research and drug development while precisely matching each patient with the best available therapy.
BostonGene will also highlight its recently announced immune system profiling platform, a novel classification method and a scoring system based on this classification of systemic immunity with patient responses to various cancer treatments. This diagnostic and analytical immune system profiling framework underscores the potential of a straightforward blood test, supported by additional clinical validation, as a tool to stratify cancer patients into responders and non-responders across different treatments.
Details about the abstracts selected for presentation can be found below:
Oral presentation
Abstract: 2015
Title: A phase Ib, window-of-opportunity study of neoadjuvant avelumab and hypofractionated proton beam therapy for recurrent radiation-relapsed meningioma
Date and time: Sunday, June 2, 2024 | 11:30 AM – 1:00 PM
Speaker: Jiayi Huang, MD, Washington University School of Medicine
This study evaluated the immunological effects of combining avelumab, an anti-PD-L1 inhibitor, with radiation therapy (RT) for recurrent radiation-relapsed meningioma. The use of RNA-seq and MxIF on pre- and post-avelumab tumor tissues revealed that for some patients the combination (avelumab + RT) may cause an immunological response leading to prolonged remission, warranting further larger prospective studies and biomarker investigations.
Research done in collaboration with the Washington University School of Medicine
Poster presentations
Abstract: 11523
Title: Transcriptomic analysis of novel tumor suppressor gene fusions in bone sarcomas
Date and time: Saturday, June 1, 2024 | 1:30 PM – 4:30 PM
Poster: 449
Speaker: Nikita Kotlov, BostonGene
Transcriptomic analysis of treated bone sarcomas revealed a unique breakpoint combination in an oncogene and previously unknown gene fusions involving tumor suppressor genes. These findings highlight the importance of RNA-seq to advance research and identify potential biomarkers for sarcomas.
Research done in collaboration with The University of Texas MD Anderson Cancer Center, Massachusetts General Hospital Cancer Center and the Sarcoma Oncology Center
Abstract: 1044
Title: The multiomic tumor microenvironment landscape of invasive lobular carcinoma of the breast
Date and time: Sunday, June 2, 2024 | 9:00 AM – 12:00 PM
Poster: 22
Speaker: Jason Mouabbi, MD, The University of Texas MD Anderson Cancer Center
Multiomic analysis using integrated RNA-seq and MxIF uncovered the intricate heterogeneity of the tumor microenvironment (TME) in invasive lobular carcinoma (ILC) of the breast, emphasizing the critical role of comprehensive TME profiling to understand and develop personalized treatments for ILC.
Research done in collaboration with MD Anderson Cancer Center
Online-only abstracts
Abstract: e13168
Title: Closing classification gaps in luminal breast cancer with single-cell RNA-seq insights from normal breast lineages
In this study, single-cell RNA-seq was used to investigate the connection between breast cancer classification and luminal expression profiles. The findings showed that compared to other breast cancer subtypes, luminal breast cancers are less similar to most luminal epithelial clusters in normal breast tissue, which suggests that the complexity of luminal-type breast cancers is not captured by traditional breast cancer classification methods.
Abstract: e15138
Title: Integrated genomic and transcriptomic characterization of neuroendocrine carcinomas for improved treatment decision-making
Integrated whole exome (WES) and RNA sequencing (RNA-seq) detected unique molecular features across diverse neuroendocrine tumors, indicating the potential use of comprehensive molecular profiling for therapy and clinical trial matching to improve outcomes for neuroendocrine carcinoma (NEC) patients.
Research conducted in collaboration with Advanced Cancer Treatment Centers, Mayo Clinic and Duke Cancer Institute
Abstract: e13593
Title: An unsupervised H&E-based machine-learning approach for precise prediction of tumor microenvironment subtypes.
This study describes the development of an H&E-based machine-learning approach using colorectal cancer (CRC) samples. The results show that the H&E-based approach complements next-generation sequencing (NGS) tumor microenvironment (TME) classification, suggesting that the advanced image analysis can help refine prognostic and therapeutic strategies for CRC and warrant further expansion to other cancer types.
Abstract: e15086
Title: Effect of DeltaRex-G ± DeltaRex-G Plus (an FDA-approved drug) on advanced chemoresistant pancreatic cancer, sarcoma, and breast cancer
This study investigated the use of DeltaRex-G, a CCNG1 inhibitor, administered either alone or in combination with an FDA-approved drug (DeltaRex-G Plus) in advanced cancers. RNA sequencing identified enhanced CCNG1 expression in all analyzed tumors and analysis showed that the five patients treated with DeltaRex-G Plus had a partial response or stable disease, supporting the use of DeltaRex-G Plus as a promising therapy.
Research conducted in collaboration with City of Hope Comprehensive Cancer Center, Sarcoma Oncology Center, Duke University and Expression Therapeutics
For more information, please visit the 2024 ASCO (Free ASCO Whitepaper) Annual Meeting website. The abstracts will be published online in the Journal of Clinical Oncology supplement for the ASCO (Free ASCO Whitepaper) Annual Meeting Proceedings.