On March 30, 2021 BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, reported that eight abstracts were selected for poster presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021, which will be conducted virtually from April 10 – 15, 2021 and May 17 – 21, 2021 (Press release, BostonGene, MAR 30, 2021, View Source [SID1234577379]).

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The presentations underscore the importance of the application of novel and cutting-edge analytical tools to improve the diagnosis and treatment for cancer patients. These tools were applied across a wide range of cancers to further understand tumor biology and identify biomarkers for diverse therapies in an effort to propel precision medicine to the forefront of clinical decision making.

"We are proud to present at the AACR (Free AACR Whitepaper) Annual Meeting. These results demonstrate BostonGene’s unique ability to identify novel and personalized treatment options through next generation multi-platform analytics, further advancing and optimizing outcomes for each cancer patient," said Nathan Fowler, MD, Chief Medical Officer at BostonGene.

Details of the poster presentations are below:

Title: AI-driven multifaceted predictive biomarkers of response to tyrosine kinase inhibition and immune checkpoint blockade in clear cell renal cell carcinoma
Session: PO.CL06.06 – Immune Response to Therapies
Poster: 516
Presenter: Natalia Miheecheva, MSc, BostonGene

Research conducted with Washington University School of Medicine in St Louis.

Title: Association of circulating myeloid derived suppressor cells with systemic lymphopenia following chemoradiotherapy in glioblastoma
Session: PO.CL06.04 – Immune Mechanisms Invoked by Therapies
Poster: 507
Presenter: Dinesh Thotala, PhD, Washington University School of Medicine in St Louis

Research conducted with Washington University School of Medicine in St Louis.

Title: Astraea: A first-in-class biomarker database integrating genomic, transcriptomic, and tumor microenvironment properties for precision oncology
Session: PO.BSB01.03 – Database Resources
Poster: 205
Presenter: Azamat Gafurov, MSc, BostonGene

Title: Evaluating the clinical utility of RNA-seq-based PD-L1 expression and cellular deconvolution as alternatives to conventional immunohistochemistry in clear cell renal cell carcinoma
Session: PO.BSB01.02 – Application of Bioinformatics to Cancer Biology
Poster: 161
Presenter: Natalia Miheecheva, MSc, BostonGene

Research conducted with Washington University School of Medicine in St Louis.

Title: Integrated multiregional transcriptomic and multi-parameter single-cell imaging analysis of clear cell renal cell carcinoma elucidates diverse cellular communities present within the tumor microenvironment
Session: PO.TB06.04 – Immune Cells in the Tumor Microenvironment
Poster: 2742
Presenter: Natalia Miheecheva, MSc, BostonGene

Research conducted with Washington University School of Medicine in St Louis.

Title: MutAnt: Mutation annotation machine learning algorithm for pathogenicity evaluation of single nonsynonymous nucleotide substitutions in cancer cells
Session: PO.BSB02.01 – Artificial Intelligence and Machine Learning
Poster: 192
Presenter: Aleksandr Sarachakov, MSc, BostonGene

Title: Predictors of treatment responses in a preoperative window of opportunity trial of nivolumab in resectable squamous cell carcinoma of the head and neck
Session: PO.ET02.03 – Role of the Microenvironment in Therapeutic Response
Poster: 1441
Presenter: Nikita Kotlov, MSc, BostonGene

Research conducted with Thomas Jefferson University.

Title: Tumor immune microenvironment based molecular functional clustering reveals a prognostic signature that predicts overall survival in patients with gastric cancer
Session: PO.TB06.08 – Tumor Immune System Interactions
Poster: 3182
Presenter: Prashant V. Thakkar, Weill Cornell Medicine

Research conducted with Weill Cornell Medicine.

The e-poster website will be launched Saturday, April 10, 2021, the first day of the AACR (Free AACR Whitepaper) Virtual Annual Meeting. All e-posters will be made available for browsing on the AACR (Free AACR Whitepaper) Annual Meeting website on this date.

Additionally, the abstracts will be published in an online-only Proceedings supplement to the AACR (Free AACR Whitepaper) journal Cancer Research after the completion of the AACR (Free AACR Whitepaper) Virtual Annual Meeting.