On May 24, 2022 Eucure Biopharma, a wholly owned subsidiary of Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen"), reported that it will present two posters at the 2022 ASCO (Free ASCO Whitepaper) Annual Meeting, taking place in Chicago, IL and virtually from June 3-7, 2022 (Press release, Eucure, MAY 24, 2022, View Source [SID1234615151]). The posters describe updates from two phase I clinical studies in Australia for internally developed monoclonal antibodies (mAbs) YH003 (anti-CD40, abstract # 2603) and YH001 (anti-CTLA-4, abstract # 2602). Both YH003 and YH001 demonstrate favorable safety and tolerability profiles and preliminary efficacy when administered in combination with anti-PD-1 mAbs to patients with advanced solid tumors.
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About YH003
YH003 is a humanized IgG2 agonistic CD40 antibody. Whether used as a single agent or in combination with anti-PD-1 mAb drugs, YH003 demonstrated strong anti-tumor effects against multiple tumor models in Biocytogen’s humanized CD40 mice, without exhibiting hepatotoxicity or other toxicities. Pharmacodynamic studies in mice indicate that YH003 significantly increased the infiltration of anti-tumor T cells into tumors. Currently, YH003 is undergoing phase II multi-regional clinical trials (MRCTs) for the treatment of patients with unresectable/metastatic melanoma and pancreatic ductal adenocarcinoma (PDAC).
About YH001
YH001 is an anti-CTLA-4 monoclonal antibody. CTLA-4 is a key target for tumor immunotherapies, due to the potential to enhance the immune response to tumor cells and promote removal of regulatory T cells from the tumor microenvironment. Blocking the inhibitory signals from both CTLA-4 and PD-1 to enhance the anti-tumor responses is considered a promising tumor immunotherapy, as they control different types of T cells. Currently, YH001 is undergoing phase II MRCTs for the treatment of patients with advanced non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Moreover, Biocytogen/Eucure Biopharma has entered into a collaborative partnership agreement with TRACON Pharmaceuticals (NASDAQ: TCON) for the development of YH001 for multiple oncology indications, including soft tissue sarcoma, in North America.