On May 20, 2024 BioCity Biopharma reported that the preliminary Phase I data of BC3195 (CDH3 ADC) as a monotherapy for advanced solid tumors, and the data from two clinical studies of SC0245 (ATR inhibitor) will be exhibited at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting 2024 (Press release, Biocity Biopharmaceutics, MAY 20, 2024, View Source [SID1234644485]). The ASCO (Free ASCO Whitepaper) Annual Meeting will be held in Chicago, USA, from May 31 to June 4, 2024.
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Detailed information is as below:
（1）Abstract Title:
BC3195, a novel ADC targeting CDH3: Preliminary results of a first-in-human phase I study in patients with advanced solid malignancies.
Abstract #：e15008
Session Type：
Publication Only—Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
lt will be published on meetings.asco.org/abstracts-presentations at 5:00 PM EDT on May 23,2024.
（2）Abstract Title:
An open-label, single-arm, dose escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of the ATR inhibitor SC0245 in advanced solid malignancies.
Session Type：
Publication Only—Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Abstract #：e15126
lt will be published on meetings.asco.org/abstracts-presentations at 5:00 PM EDT on May 23,2024.
（3）Abstract Title:
An open-label, multicenter, phase Ib/II study of the ATR inhibitor SC0245 in combination with irinotecan in patients with relapsed and refractory extensive stage small cell lung cancer (ES-SCLC).
Session Type:
Poster Session—Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers
Session date and time:
June 3，2024，from 1:30 p.m.~4:30 p.m. (Central Daylight Time)
Poster Bd #：364
About BC3195
BC3195 is currently the only ADC targeting CDH3/P-Cadherin in clinical development globally. In preclinical studies, BC3195 binds to cell surface CDH3 with strong affinity and is efficiently internalized. BC3195 is designed with a clinically validated, cleavable linker and payload (vc-MMAE) allowing for the destruction of targeted tumor cells as well as surrounding cells which is known as the bystander effect. In animal models, BC3195 demonstrated a favorable safety profile and strong antitumor activity with tumor growth inhibition of ≥100%.
BC3195 is in parallel clinical development in both China and the US. Prof. Yilong Wu from Guangdong Provincial People’s Hospital and Prof. Bob Li from MSK Cancer Center are leading the studies in these territories, respectively.
About SC0245
SC0245 is the first small molecule ATR Kinase inhibitor that entered clinical development stage in China and ranked in the top tier globally.
SC0245 exhibited strong ATR kinase inhibition potency in preclinical studies. In multiple animal models, SC0245 demonstrated favorable safety, tolerability, and pharmacokinetic profiles. SC0245 also exhibited strong antitumor activity as a single agent or in combination with other therapeutics in these models.
In a phase I clinical study led by Prof. Lin Shen at Beijing Cancer Hospital, SC0245 demonstrated favorable safety and tolerability profiles, and a high disease control rate.
SC0245 is now in a phase Ib/II clinical study in combination with irinotecan for the treatment of small cell lung cancer. This study is led by Prof. Shun Lu, oncology department director at Shanghai Chest Hospital.