On January 24, 2020 BERG, a biopharmaceutical company that merges biology with technology to map and identify drivers of diseases, reported the presentation of initial results from a Phase 2 clinical trial at the Gastrointestinal Cancer Symposium (ASCO-GI), being held in San Francisco from January 23 – 25, 2020 (Press release, Berg, JAN 24, 2020, View Source [SID1234553542]). The presentation provides details on the analysis of a Phase 2 clinical trial using BPM31510 in Pancreatic Ductal Adenocarcinoma (PDAC) refractory to current standard of care. Initial results demonstrated preliminary efficacy in patient’s refractory to chemotherapy regimens and identification of potential biomarkers of survival guided by the use of the BERG Interrogative Biology platform.
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"Interrogative Biology has enabled BERG to unravel unique insight into interconnected pathways that drive cancer by mapping the nature of disease biology through patient data and Bayesian AI," said Dr. Niven R. Narain, BERG Co-founder, President and Chief Executive Officer. "The research presented this week at ASCO (Free ASCO Whitepaper)-GI further demonstrates how the BERG platform can enhance and improve development of treatments for pancreatic cancer through discovery and validation of biomarkers to improve patient outcomes."
"Pancreatic cancer has continually remained elusive to successful development of novel therapeutic compounds. The observation of an efficacy signal and the parallel use of BERG’s platform to identify biomarkers predictive of response significantly increases chances of successful development of BPM31510," said Dr. Madappa Kundranda, Director Gastrointestinal Cancer Program, Banner MD Anderson Cancer Center, AZ and Principal Investigator at his clinical trial site.
For this trial, BERG has collaborated with leading institutions such as Banner MD Anderson, Gilbert, AZ; Bart’s Cancer Institute, Queen Mary University of London, UK; Medical College of Wisconsin, Milwaukee, WI; Mary Crowley Cancer Center, Dallas, TX; Beth Israel Medical Center/Harvard Medical School, Boston, MA, Royal Free London, UK; Mayo Clinic, Phoenix, AZ; Atlantic Health Systems, Morristown, NJ; Global Cancer Research Institute, San Jose, CA; Sarcoma Cancer Center, Santa Monica, CA; and Vita Medical Associates Bethlehem, PA. BERG is grateful to its patients and family partners and their participation in these critical efforts to improve patient care.
Details of the data presentations include:
Abstract Submission ID: 284735
Abstract Number: 723
Poster Board: L12
Abstract Title: Phase II trial of BPM31510-IV plus gemcitabine in advanced pancreatic ductal adenocarcinomas (PDAC).
Session Information:
Poster Session B: Hepatobiliary Cancer, Neuroendocrine/Carcinoid, Pancreatic Cancer, and Small Bowel Cancer
Session Date & Time:
1/24/2020, 12:00 PM-1:30 PM; 4:30 PM-5:30 PM