On March 26, 2025 Bantam Pharmaceutical, a drug discovery and development company targeting selective modulation of mitochondrial dynamics in cancer, reported that its abstract has been accepted for presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, which is being held April 25-30, 2025 at the McCormick Place Convention Center in Chicago, Illinois (Press release, Bantam Pharmaceutical, MAR 26, 2025, View Source [SID1234651483]). The poster presentation will highlight solid tumor regression data from Bantam’s lead product candidate, BTM-3566. BTM-3566 is a first-in-class, small molecule cancer therapeutic which targets difficult-to-treat aggressive tumors by activating the OMA1-ATF4 Integrated Stress Response (ISR), a newly described mitochondrial homeostasis pathway. Leveraging its unique mechanism of action, BTM-3566 demonstrated robust activity as a single agent in vivo in solid tumors with low FAM210B RNA expression. Additionally, preclinical data suggest that rational combinations with BH3 mimetics could extend the therapeutic potential of BTM-3566, particularly in difficult-to-treat tumors.
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Poster Presentation Details
Title: Selective pharmacological activation of the mitochondrial protease OMA1 inhibits tumor growth and induces regression in tumors expressing low levels of FAM210B
Presenter: Matthew Kostura, PhD, Chief Scientific Officer, Bantam Pharmaceutical
Session: Experimental and Molecular Therapeutics
Date/Time: Monday, April 28th at 3 p.m. to 6 p.m. ET
Abstract Number: 3032
Additional meeting information can be found on the AACR (Free AACR Whitepaper) website, View Source The poster presentation will be made available under the News & Resources section of the company’s website shortly after the event.
About BTM-3566
BTM-3566 is a novel, orally available small molecule designed to target a wide range of cancers, including both hematologic and solid tumors. Its initial clinical focus is on mature B-cell lymphomas, such as mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and follicular lymphoma (FL). In preclinical studies, BTM-3566 demonstrated potent anti-cancer activity, driving significant tumor regression – and in many cases, complete tumor elimination – in models resistant to standard treatments, including CAR-T cell therapy. BTM-3566 works by disrupting the mitochondrial function in tumor cells, triggering their natural cell death process (apoptosis). With its unique mechanism of action and strong preclinical data, Bantam also plans to expand clinical development into solid tumors, broadening its potential impact for patients with limited treatment options.
Currently, Bantam is conducting an ongoing Phase 1 clinical trial in both the U.S. and Canada evaluating BTM-3566 in relapsed/refractory mature B-cell lymphomas. For more information about the U.S. trial, visit ClinicalTrials.gov and search NCT06792734.