On September 3, 2024 Avenzo Therapeutics, Inc. ("Avenzo"), a clinical-stage biotechnology company developing the next generation of oncology therapeutics, reported it has entered into a clinical study collaboration and supply agreement with Gilead Sciences, Inc. ("Gilead") to evaluate the safety and efficacy of AVZO-021, its investigational, potentially best-in-class CDK2 inhibitor, in combination with Gilead’s Trodelvy (sacituzumab govitecan-hziy), a Trop-2 directed antibody-drug conjugate (ADC), as a potential treatment for patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer (Press release, Avenzo Therapeutics, SEP 3, 2024, View Source;Metastatic-Breast-Cancer [SID1234646330]).
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"We are excited to advance our oncology pipeline by entering this clinical collaboration with Gilead to evaluate the combination potential of AVZO-021," said Athena Countouriotis, M.D., Co-founder, President and CEO of Avenzo Therapeutics. "We continue to believe AVZO-021 is a potential best-in-class CDK2 selective inhibitor that may provide a new treatment option to patients. We look forward to initiating combination cohorts with Trodelvy, as well as CDK4/6 inhibitors, in the Phase 1b portion of the ongoing clinical study in the fourth quarter of 2024."
Under the clinical study collaboration and supply agreement, Gilead will provide Trodelvy to Avenzo, who will conduct and sponsor the combination study. Avenzo and Gilead will retain all development and commercial rights to their respective compounds, including as monotherapy or as combination therapies.
Trodelvy and Gilead are trademarks of Gilead Sciences, Inc., or its related companies.