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REGiMMUNE Completes $9.2 Million Series D Financing

On February 14, 2014 REGiMMUNE Corporation reported the closing of a Series D financing earlier this month (Press release, REGimmune, FEB 14, 2014, View Source [SID1234642236]). The company raised $9.2 million US in this new round, which was led by Japan Asia Investment Corporation (JAIC) and Nippon Venture Capital Corp (NVCC). Additional investors participating in this round are new investors Mizuho Capital, Nissei Insurance, KSP, Inc., the core business entity that operates the Kanagawa Science Park, and Mitsui Sumitomo Insurance Venture Capital Co.,Ltd.. Existing investors SMBC Venture Capital Co., Ltd., the VC arm of Sumitomo Mitsui Banking Corporation, and Mitsubishi UFJ Bank Capital also invested in this financing. Proceeds from this funding will be used primarily to support the company’s early stage product development.
REGiMMUNE successfully completed a Phase I study of RGI-2001 for Graft versus Host Disease (GvHD) and recently announced it has initiated a Phase II clinical trial for RGI-2001. Data from the Phase I study showed no safety concerns up to the highest dose and some preliminary signs of efficacy were observed.
Haru Morita, President and Chief Executive Officer, said "We now have positive human clinical data that validates the usefulness of our immune-regulating technology platform. The financing announced today will allow us to fund new programs based on our proprietary technology including therapeutics for type 1 diabetes, celiac disease, and inhibitor formation in enzyme replacement therapies (ERT) such as hemophilia and lysosomal diseases."

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Xenetic Biosciences Announces Ticker Symbol Change to XBIO

On February 14, 2014 Xenetic Biosciences, Inc. (OTCBB:XBIO), a biopharmaceutical company focused on developing next-generation biologic drugs and novel oncology therapeutics, reported that its common stock has commenced trading under new ticker symbol "XBIO" on the OTC Bulletin Board (OTCBB). Since changing its name in January, the Company has traded on the OTCBB under the ticker symbol "GAIFD (Press release, Xenetic Biosciences, FEB 14, 2014, View Source [SID1234537822])."

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Scott Maguire, CEO of Xenetic said, "We are pleased with our new ticker, which is more shareholder friendly and better represents Xenetic. This new XBIO ticker, together with our recent announcements regarding the appointment to our Board of Directors of Dr. Tim Coté, the former Director of the U.S. Food and Drug Administration Office of Orphan Products Development, and our recent agreement with Baxter Healthcare SA, which included an upfront $10 million equity investment and $100 million in potential future cash milestones, represent a major step toward making Xenetic a significant drug development player in the U.S. markets."

Xenetic currently has a total of 146,740,691 shares of common stock issued and outstanding, taking into account the Baxter investment in January, which resulted in the issuance of an additional 10,695,187 shares of common stock.

(Filing, 10-K, , FEB 14, 2014, View Source [SID:1234502762])

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AVEO and Astellas to End Worldwide Collaboration License Agreement for Development and Commercialization of Tivozanib

On February 14, 2014 AVEO Oncology and Astellas Pharma said the companies will end their worldwide collaboration and license agreement for the development and commercialization of investigational agent tivozanib. Astellas has exercised its right to terminate the agreement signed in 2011 for strategic reasons, based on the clinical status of the three indications studied (Press release AVEO, FEB 14, 2014, View Source [SID:1234500080]). Additionally, the companies agreed to discontinue the ongoing Phase II BATON (Biomarker Assessment of Tivozanib in ONcology) study in patients with colorectal cancer (CRC). The termination of the collaboration will be effective August 11, 2014 at which time tivozanib rights will be returned to AVEO. In accordance with the collaboration and license agreement, committed development expenses will be shared equally.

(Press release, Selvita, FEB 11, 2014, View Source [SID:1234504702])

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