FPA008 is an anti-CSF1R antibody that block the ability of IL-34 and CSF1 to bind to and activate CSF1R which is under development by Five Prime for the treatment of autoimmune disorders and cancer (Company Pipeline Five Prime Therapeutics, NOV 25, 2014, View Source [SID:1234501014]).

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New pipeline entries: L1CAM product candidate, MUC-16/IL-12 product candidate, ROR-1 product candidate (Company Pipeline Juno, NOV 25, 2014, View Source [SID:1234501013]).

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JCAR016 is a high-affinity TCR T cell product candidate targeting WT-1 which is under development by Juno Therapeutics for the treatment of cancer (Company Pipeline Juno, NOV 25, 2014, View Source [SID:1234501012]).

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The TCR constructs used by Juno are selected by screening healthy donors for naturally-occurring high-affinity TCRs against a MHC/peptide combination of interest (Company Pipeline Juno, NOV 25, 2014, View Source [SID:1234501011]). Depending on the binding affinity of the selected TCR construct, it is either used directly or modified by mutating a specific region, the hypervariable domain, of the TCR binding pocket to create a higher affinity construct. Due to the variability of MHC types across the human population, different TCRs will be required for various segments of the population.

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On November 24, 2014 Genmab reported that its collaboration partner, Janssen Biotech, Inc. (Janssen) plans to start a Phase II study of daratumumab in smoldering multiple myeloma (Press release Genmab, NOV 24, 2014, View Source [SID:1234501009]). The study (SMM2001) will evaluate three different dose schedules of daratumumab for the treatment of smoldering multiple myeloma. The study is expected to start enrolling patients in 2015.

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"We are pleased to announce this study, which illustrates that the development plan for daratumumab encompasses all stages of multiple myeloma. Smoldering multiple myeloma is a challenging indication, as physicians will evaluate treating patients at an early stage of the disease, with the intent to extend the period before the disease transitions to symptomatic multiple myeloma," said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab.