On March 21, 2012 Addex Pharmaceuticals (SIX:ADXN), a leading company pioneering allosteric modulation-based drug discovery and development, reported that it has changed its name to Addex Therapeutics (Press release, Addex Therapeutics, MAR 21, 2012, View Source;cHash=0fa4be2499463f7ab80ff5371e18b249 [SID:1234513477]). The name change reflects more closely the company’s focus on oral small molecule-based therapeutics. Addex’s ticker symbol on the Swiss Stock Exchange remains unchanged at ADXN.

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Alongside the name change, Addex has revealed a new logo and website. The icon in the logo represents two things: the letter "X" from the Addex name and a receptor bound by a natural ligand or cell signaling molecule in the active site, depicted in blue, and an allosteric modulator bound to an allosteric site, in orange.

Addex has also introduced a new tag line: "expanding the realm of possible…" which is literally what the allosteric approach is doing for drug discovery. When applied to drug discovery, allostery offers the unique possibility of developing oral small molecule drugs for targets that were previously considered "undruggable" with conventional drug discovery approaches. Addex technology, therefore, expands the realm of druggable targets.

The new website provides information on the company’s strategy, pipeline and the allosteric modulation-based drug discovery and development technology platform. The new website also provides helpful information on the stock, corporate governance and corporate calendar featuring the company’s investor, media and scientific outreach activities.

This name change is subject to shareholder approval.

(Filing, 10-K, Cleveland BioLabs, MAR 13, 2012, View Source [SID:1234503832])

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(Press release, Cannabis Science, MAR 12, 2012, View Source [SID:1234505821])

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(Filing, 10-K, Oncothyreon, MAR 9, 2012, View Source [SID:1234504092])

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On March 6, 2012 Apexigen and Gansu Duyiwei Biological Pharmaceutical reported that they entered into a collaboration to grant an exclusive license to GDBP to develop and commercialize APX004 in China (Press release, Apogenix, MAR 6, 2012, View Source [SID:1234500908]). APX004 is a humanized monoclonal antibody directed against VEGFR2 for the treatment of certain cancers and angiogenic diseases. Under this agreement, GDBP will have an exclusive license and sole responsibility to research, develop and commercialize APX004 in China. Apexigen retains all rights to APX004 outside of China and will collaborate with GDBP to advance the development program. Under the terms of the agreement, Apexigen will receive an upfront payment, milestone payments on the successful achievement of regulatory milestones, and a royalty. Financial terms were not disclosed.

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"The pharmaceutical market in China today is very dynamic. We are pleased to be partnering with Gansu Duyiwei for the development and commercialization of APX004 in this vibrant market. We’re looking forward to a productive partnership," said Dr. Xiaodong Yang, Apexigen’s President and CEO.

"During the last century, people often said that the century to come will be the biological science century. The report of a survey from an American marketing research institute, Alt Assets, shows that the prospects for the global biotechnology industry are very promising. The sales revenue for products of the bio-economy, that is, products based on biological science and biotechnology, will exceed 15 trillion US Dollars in 30 years and the bio-economy will outrun the information economy and become the most powerful economic force in the world. The cooperation between Duyiwei and Apexigen will become a developmental milestone for Duyiwei. Based on its efforts, flexible mode of R&D and the continually increased investment on R&D, Duyiwei has the confidence and determination to constantly launch a series of original products in the near future to bring hope to the diseased and improve their quality of living," said Dr. Zhiping Duan, CEO of Gansu Duyiwei.