(Press release, EGEN Inc, JUN 5, 2013, View Source;advances-a-systemically-delivered-rnai-therapeutic-for-the-treatment-of-pulmonary-arterial-hypertension-pah-210247491.html [SID:1234504979])

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(Press release, Inflection Biosciences, JUN 4, 2013, View Source [SID:1234503414])

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Vernalis and Servier Extend Oncology Collaboration

On March 6, 2013 Vernalis plc and Servier, France’s largest privately-owned pharmaceutical company, reported the further extension of their ongoing oncology collaboration initiated in May 2007 (Press release, Servier, JUN 3, 2013, View Source [SID:1234508823]).

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This is the first of three collaborations between Vernalis and Servier and focuses on multiple undisclosed oncology targets. It was initially extended in October 2011 and is now extended for a further two years.

Ian Garland, CEO of Vernalis, commented "We are delighted by this news which reflects Servier’s continued endorsement of our joint achievements over the past few years."

Servier’s head of research, Bernard Marchand, said: "this 2-year extension highlights our commitment to cancer research through innovative drug discovery platforms."

PERNIX THERAPEUTICS COMPLETES ACQUISITION OF CYPRESS PHARMACEUTICALS, INC. AND HAWTHORN PHARMACEUTICALS, INC.

On January 2, 2013 Pernix Therapeutics Holdings, Inc. ("Pernix" or the "Company") (NYSE MKT: PTX), a specialty pharmaceutical company, reported that it has completed the acquisition of Cypress Pharmaceuticals, Inc. ("Cypress"), a privately-owned generic pharmaceutical company, and Hawthorn Pharmaceuticals, Inc. ("Hawthorn"), a privately-owned branded pharmaceutical company (Press release, Pernix Therapeutics , JUN 2, 2013, View Source;p=irol-newsArticle&ID=2123575 [SID1234517243]). Under the terms of the definitive agreement announced on November 14, 2012 and as amended on December 28, 2012, Pernix will pay up to $102 million, including an up-front payment of $52.0 million in cash and $34.0 million in equity (approximately 4.4 million shares of the Company’s common stock) at closing as well as up to $11 million payable in December 2013 and an additional $5 million in a milestone payment.

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In connection with the closing of the acquisition, the Company completed a $42 million credit facility. MidCap Financial served as Sole Bookrunner, Administrative Agent and Co-Lead Arranger. Cypress and Hawthorn significantly increases and broadens the Company’s branded and generic product portfolio. Cypress and Hawthorn also have clinical and regulatory expertise, receiving approval of more than 10 ANDAs in the last three years and 2 NDAs in 2011. In addition, 15 ANDAs and one 505(b)(2) NDA were filed at the FDA, and Cypress and Hawthorn also have several products in clinical development.

Cooper Collins, President and CEO of Pernix, said, "We are pleased to close on this transaction before the end of the year. We believe the acquisition of Cypress and Hawthorn are an excellent fit for Pernix, and will serve as a key driver for the company’s future growth. We plan to rapidly integrate the branded business of Hawthorn and the generic business of Cypress, and we expect to capitalize on the synergies of the combined companies."

BeiGene and Merck KGaA enter into global co-develop and commercialization agreement for cancer therapy

On May 31, 2013 BeiGene and Merck KGaA reported that they have entered into a global licensing, co-development, and commercialization agreement for BeiGene-283 (Press release BeiGene, MAY 31, 2013, View Source [SID:1234500415]).
The compound is a second-generation BRAF inhibitor for the treatment of cancer. BeiGene-283, which is currently in preclinical development, was discovered and developed in the People’s Republic of China by BeiGene. It is expected to enter clinical development next year. BRAF inhibitors target a protein (BRAF) that is a downstream component of the MAPK pathway, which is thought to promote cancer cell growth and is dysregulated in a number of human cancers.
Under the terms of the collaboration, BeiGene will be responsible for the development and commercialization of BeiGene-283 in the People’s Republic of China and Merck KGaA will be responsible for the development and commercialization of BGB-283 for the rest of the world. BeiGene will receive an undisclosed upfront payment and is eligible to receive further payments of up to US$ 233 million for the achievement of clinical development and potential commercial milestones in both the People’s Republic of China and rest of the world, as well as up to double digit royalties on net sales.

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