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DNAtrix Awarded $10.8 Million Grant by the Cancer Prevention and Research Institute of Texas

On February 24, 2014 DNAtrix was awarded a product development grant for $10.8 million to fund the company’s clinical-stage program in glioblastoma (Press release DNAtrix, FEB 24, 2014, View Source [SID:1234500126]). The grant from the Cancer Prevention and Research Institute of Texas (CPRIT) is entitled "Clinical development and commercialization of oncolytic adenovirus for treating malignant glioma."
The grant awarded to DNAtrix will be used to drive the clinical development of DNX-2401, the lead product candidate that is currently undergoing a Phase Ib trial in combination with temozolomide for recurrent glioblastoma. DNX-2401 uses a genetically modified adenovirus that kills tumor cells selectively. In an earlier Phase I study in recurrent glioblastoma, DNX-2401 demonstrated an excellent safety profile and promising efficacy results.

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Synta Reports on Progress with Lead HDC Compounds at IASLC Conference

On February 24, 2014 Synta reported on progress with lead compounds from its Hsp90-Inhibitor Drug Conjugate (HDC) platform at the IASLC 14th Annual Targeted Therapies of the Treatment of Lung Cancer Meeting in Santa Monica, California (Press release Synta Pharmaceuticals, FEB 24, 2014, View Source [SID:1234500122]). The new compounds, consisting of an Hsp90-inhibitor conjugated with SN-38 (HDC SN-38) and an Hsp90-inhibitor conjugated with docetaxel (HDC docetaxel), demonstrated proof of principle in multiple preclinical cancer models. Notably, complete or near complete regressions of tumors were observed in models of non-small cell lung cancer, small-cell lung cancer, breast cancer, pancreatic cancer, colon cancer, and skin cancer, in models that are generally resistant or show limited response to treatment with the unconjugated chemotherapies.
Results presented at the conference showed that up to seven times greater dosage of docetaxel may be safely administered in the animal models compared to unconjugated docetaxel. This increase was associated with near complete regressions in animals treated with the HDC vs. limited activity or progressive disease in animals treated with unconjugated docetaxel. Preclinical safety results to date show comparable or more favorable safety profile of the HDC as compared with the unconjugated chemotherapy.
In addition, both the SN-38 and docetaxel HDCs demonstrated prolonged anti-tumor activity following the last dose of the HDC. These results are consistent with retention of the HDC in tumors and sustained, slow release of the cytotoxic payload within the tumor.
Slides presented at the IASLC meeting are available here View Source .

Sym013

Sym013 is a mixture of six humanized full length monoclonal antibodies targeting EGFR, HER2 and HER3 which is under development by Symphogen for the treatment of cancer (Company Pipeline Symphogen, FEB 22, 2014, View Source [SID:1234500115]).

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Sym015

Sym015 is a multi targeting mAb mixture program against undisclosed receptor tyrosine kinase target and stromal target which is under development by Symphogen for the treatment of cancer (Company Pipeline Symphogen, FEB 22, 2014, View Source [SID:1234500117]).

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Sym014

Sym014 belongs to an antibody drug conjugate program against undisclosed receptor tyrosinekKinase target.which is under development by Symphogen for the treatment of leukemia (Company Pipeline Symphogen, FEB 22, 2014, View Source [SID:1234500116]).

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