Halozyme To Present Nonclinical Data At SITC 2017 Supporting Combination Of PEGPH20 With Checkpoint Inhibitors

On November 10, 2017 Halozyme Therapeutics, Inc. (NASDAQ: HALO) reported that it will present nonclinical data at the 32nd Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) which demonstrate the potential for PEGPH20, Halozyme’s pegylated recombinant human hyaluronidase, to increase the infiltration of immune cells into the tumor microenvironment and enhance the efficacy of immuno-oncology drugs in an HA-accumulating murine colon tumor model (Press release, Halozyme, NOV 10, 2017, View Source [SID1234521938]).

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The study shows that degradation of hyaluronan (HA) in a tumor by PEGPH20 can facilitate an anti-tumor immune response induced by checkpoint blockade by promoting effector cell infiltration and skewing the immune microenvironment toward a more anti-tumor composition. The data support Halozyme’s ongoing clinical evaluation of PEGPH20 in combination with checkpoint inhibitors.

The poster, entitled "Degradation of hyaluronan by PEGPH20 promotes anti-tumor immunity and enhances the effect of checkpoint blockade in an HA-accumulating mouse syngeneic tumor model," will be presented as part of a series of posters focusing on the tumor microenvironment from 12:30 p.m. to 2 p.m. EST on Saturday, November 11.

Northern Presents Phase 1 Trial Poster at SITC Conference

On November 10, 2017 Northern Presented Phase 1 Trial Poster at SITC (Free SITC Whitepaper) Conference.(Presentation, Northern Biologics, NOV 10, 2017, View Source [SID1234521940])

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ZIOPHARM to Present at the Stifel 2017 Healthcare Conference

On November 10, 2017 ZIOPHARM Oncology, Inc. (Nasdaq:ZIOP) reported that David Mauney, M.D., CBO and interim COO, will present at the Stifel 2017 Healthcare Conference in New York on Tuesday, November 14, 2017 at 11:00 a.m. ET (Press release, Ziopharm, NOV 10, 2017, View Source [SID1234521941]).

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To access a live audio webcast of the presentation, please visit the Investor Relations section at www.ziopharm.com. The webcast will be archived for 90 days.

Symposium and Panel Discussion on Nymox’s Fexapotide To Be Held at American Urological Association North Central Section Annual Meeting in Scottsdale AZ November 15

On November 10, 2017 Nymox Pharmaceutical Corporation (NASDAQ:NYMX) reported that a Symposium on Fexapotide Triflutate studies will be held at the Annual Meeting of the American Urological Association North Central Section, in Scottsdale AZ next week (Press release, Nymox, NOV 10, 2017, View Source;fvtc=4&fvtv=6907 [SID1234521932]). The symposium, "Fexapotide Triflutate: Long-Term BPH Studies 2009-2017" will be chaired by Mohamed Bidair MD of San Diego CA. The other panel members at the Symposium will be Alan Hay MD FACS of Salem OR, Stephen Richardson MD of Salt Lake City UT, and Barton Wachs MD of Long Beach CA.

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Nymox’s lead drug Fexapotide has been in development for over 10 years and has been tested by expert clinical trial investigative teams in over 70 distinguished clinical trial centers throughout the US, and has been found after 7 years of prospective placebo controlled double blind studies of treatment of 995 U.S. men with prostate enlargement to not only show clinically meaningful and durable relief of BPH symptoms, but also to show a major reduction in the incidence of prostate cancer, compared to placebo and compared to the known and expected normal incidence of the disease. The same clinical program has also shown in a long-term blinded placebo crossover group study an 82-95% reduction in the number of these patients who required surgery after they received crossover Fexapotide in the trial, as compared to patients who did not receive Fexapotide but instead received crossover conventional approved BPH treatments (p<.0001).

The Symposium will present detailed clinical data on the Phase 3 clinical trials that have been completed for Fexapotide and that have shown excellent safety and significant efficacy for the treatment of BPH. In addition, scientific data supporting the safety and efficacy from non-clinical and laboratory testing and analysis will be demonstrated. The main presentation will be followed by a panel discussion and by an interactive question and answer session with the specialist doctors in attendance.

For more information please contact [email protected] or 800-936-9669.

Forward Looking Statements

To the extent that statements contained in this press release are not descriptions of historical facts regarding Nymox, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including statements regarding the need for new options to treat BPH and prostate cancer, the potential of Fexapotide to treat BPH and prostate cancer and the estimated timing of further developments for Fexapotide. Such forward-looking statements involve substantial risks and uncertainties that could cause our clinical development program, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the clinical drug development process, including the regulatory approval process, the timing of Nymox’s regulatory filings, Nymox’s substantial dependence on Fexapotide, Nymox’s commercialization plans and efforts and other matters that could affect the availability or commercial potential of Fexapotide. Nymox undertakes no obligation to update or revise any forward looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of Nymox in general, see Nymox’s current and future reports filed with the U.S. Securities and Exchange Commission, including its Annual Report on Form 20-F for the year ended December 31, 2016, and its Quarterly Reports.

Aduro Biotech Announces Promising Preclinical Data that Validate Anti-CTLA-4 Antibody ADU-1604

On November 10, 2017 Aduro Biotech, Inc. (Nasdaq:ADRO), a biopharmaceutical company with three distinct immunotherapy technologies, reported data from preclinical studies with ADU-1604, the company’s humanized anti-CTLA-4 monoclonal antibody. Data from these in vitro and in vivo studies demonstrate the potency of ADU-1604 and its ability to inhibit tumor growth and enhance T cell-dependent antibody responses (Press release, Sangamo Therapeutics, NOV 10, 2017, View Source;p=RssLanding&cat=news&id=2316178 [SID1234521919]). These data, which will be highlighted later today in a poster presentation (Poster #335) at the 32ND Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper), underscore the potential application of ADU-1604 for the treatment of multiple cancer types, either as monotherapy or in combination with other therapies.

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"These data from preclinical studies of ADU-1604, a novel anti-CTLA-4 product candidate derived from our proprietary B-select antibody platform, are encouraging and provide support to file an Investigational New Drug Application to advance ADU-1604 into clinical studies," stated Andrea van Elsas, Ph.D., chief scientific officer of Aduro Biotech. "As a company with multiple programs and proprietary technology platforms, we are well positioned to leverage our product candidates, as monotherapies and in rational combinations, to develop new treatment options for patients in need."

Presentation Title: Characterization of a novel differentiated anti-CTLA-4 antibody (ADU-1604) in vitro and in vivo
Researchers conducted in vitro and in vivo studies comparing ADU-1604 to benchmark anti-CTLA-4 antibodies 10D1 (‘ipilimumab’) and CP-675,206 (‘tremelimumab’). Data from these studies demonstrate that ADU-1604 binds to a unique epitope on a human CTLA-4 (hCTLA-4) and is at least comparable to benchmarks in functionality. Data from in vivo studies using a well-established humanized mouse model of non-small cell lung cancer and a non-human primate model, demonstrate that ADU-1604 inhibits tumor growth and enhances T cell responses, respectively. Further, proof of concept studies in syngeneic mouse models demonstrate that anti-CTLA-4 further enhances anti-tumor activity when used in combination with ADU-S100 (also known as MIW815), Aduro’s lead investigational STING agonist, and in combination with Aduro’s proprietary immunotherapy platform of live-attenuated double-deleted Listeria monocytogenes strains (LADD).

About CTLA-4
Cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) is a negative regulator of T‐cell responses and is an immune checkpoint. Blocking CTLA-4 using antibodies may produce an anti-tumor response by enhancing T cell activation and their cancer cell killing activity in the tumor. This therapeutic target has been clinically validated by others in advanced melanoma. Aduro is developing a proprietary humanized anti-CTLA-4 antibody (ADU-1604) that binds to a unique epitope and its potency has been demonstrated in vitro and in vivo. Based on preclinical studies, Aduro believes that ADU-1604 when combined with innate and adaptive immune cell stimulators, such as STING agonists and cancer vaccines, can display an amplified anti-tumor effect against poorly immunogenic tumors. Aduro’s CTLA-4 antibody is being advanced through IND-enabling studies.