On September 27, 2018 Janssen Biotech, Inc. (Janssen) reported its decision not to continue the collaboration and license agreement with Geron Corporation for imetelstat (Press release, Johnson & Johnson, SEP 27, 2018, View Source [SID1234529885]). The decision not to continue the collaboration is the result of a strategic portfolio evaluation and prioritization of assets within the robust Janssen portfolio. Janssen will work with Geron to transition the imetelstat program back to the company. Patients currently enrolled in the ongoing imetelstat clinical trials will continue to be supported through the respective trial protocols, including treatment and follow-up. The imetelstat collaboration began on November 13, 2014 when Janssen entered into an exclusive worldwide collaboration and license agreement with Geron to develop and commercialize imetelstat in oncology, including hematologic myeloid malignancies. About the Janssen Pharmaceutical Companies of Johnson & Johnson At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com. Follow us at www.twitter.com/JanssenGlobal. Janssen Biotech, Inc. is one of the Janssen Pharmaceutical Companies of Johnson & Johnson. Media Inquiries: Brian Kenney Phone: 1-215-620-0111 Satu Kaarina Glawe Phone: +49 172 294 6264 Investor Relations: Christopher DelOrefice Phone: 1-732-524-2955 Lesley Fishman Phone: 1-732-524-3922 U.S. Medical Inquiries: 1-800-526-7736 View original content:View Source SOURCE Janssen Biotech, Inc. News Provided by Acquire Media

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On September 27, 2018 Checkpoint Therapeutics, Inc. ("Checkpoint") (NASDAQ: CKPT), a Fortress Biotech (NASDAQ: FBIO) company, reported that James F. Oliviero, President and Chief Executive Officer of Checkpoint, will present a company overview at the Ladenburg Thalmann 2018 Healthcare Conference on Tuesday, October 2, 2018, at 2 p.m. EDT (Press release, Checkpoint Therapeutics, SEP 27, 2018, View Source [SID1234529734]). The conference will be held at the Sofitel New York in New York City.

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A live webcast of the presentation will be available on the Events page of the Investors & Media section of Checkpoint’s website: www.checkpointtx.com.

On September 27, 2018 Eagle Pharmaceuticals, Inc. ("Eagle" or "the Company") (NASDAQ: EGRX) reported that Scott Tarriff, Chief Executive Officer, and Pete Meyers, Chief Financial Officer, will present at the Cantor Global Healthcare Conference as follows (Press release, Eagle Pharmaceuticals, SEP 27, 2018, View Source [SID1234529679]):

Date: Wednesday, October 3, 2018
Time: 9:10 a.m. Eastern Daylight Time
Location: Intercontinental New York Barclay Hotel, NYC
Webcast: View Source

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The presentation will be webcast live at the aforementioned time, and archived for 30 days thereafter, via the Company’s website at www.eagleus.com, under the Investors + News Section.

On September 27, 2018 VBI Vaccines Inc. (NASDAQ: VBIV) ("VBI"), a commercial-stage biopharmaceutical company developing next-generation infectious disease and immuno-oncology vaccines, reported that the independent Data and Safety Monitoring Board (DSMB) completed its second safety assessment of the ongoing Phase 1/2a clinical study of VBI-1901 in recurrent GBM (Press release, VBI Vaccines, SEP 27, 2018, View Source [SID1234529675]). The DSMB reviewed the complete safety data from the fully enrolled, intermediate-dose patient cohort, and unanimously recommended the continuation of the study without modification.

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Following this recommendation, VBI has initiated enrollment in the high-dose arm of the study. One final, pre-specified DSMB review is expected to occur after completion of enrollment in the high-dose cohort, concluding the dose-escalation phase of the study.

"We are encouraged by the sustained clean safety profile of VBI-1901 as concluded by this second DSMB assessment," said Jeff Baxter, VBI’s President and CEO. "These positive safety reviews are critical milestones for the program and for patients diagnosed with this extremely aggressive tumor who currently have no effective treatment options. With active clinical study sites at the Columbia University Medical Center, Dana-Farber Cancer Institute, and Massachusetts General Hospital, we hope to complete enrollment in this high-dose cohort quickly and look forward to announcing initial immunologic data from the low- and intermediate-dose cohorts expected later this year."

About the Phase 1/2a Study Design

VBI’s two-part Phase 1/2a study is a multi-center, open-label, dose-escalation study of VBI-1901 in up to 28 patients with recurrent GBM:

Part A: Dose-escalation phase to define the safety, tolerability, and optimal dose level of VBI-1901 in recurrent GBM patients. This phase is expected to enroll up to 18 patients in three dose cohorts.
Part B: A subsequent extension of the optimal dose level, as defined in the dose escalation phase. This phase is expected to enroll an expanded cohort of approximately 10 additional patients.

VBI-1901 is administered intradermally and is adjuvanted with granulocyte-macrophage colony-stimulating factor (GM-CSF), a potent adjuvant that mobilizes dendritic cell function. Patients in both phases of the study will receive vaccine every four weeks until tumor progression.

Additional information, including a detailed description of the study design, eligibility criteria, and investigator sites, is available at ClinicalTrials.gov using identifier NCT03382977.

On September 27, 2018 Tocagen Inc. (Nasdaq: TOCA), a clinical-stage, cancer-selective gene therapy company, reported that members of the leadership team will present at the following upcoming investor conferences in New York City (Press release, Tocagen, SEP 27, 2018, View Source;p=RssLanding&cat=news&id=2369348 [SID1234529674]):

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Tuesday, October 2, 10:30 a.m. ET
Ladenburg Thalmann 2018 Healthcare Conference
Presenter: Chief Executive Officer Marty Duvall

Wednesday, October 3, 8:00 a.m. ET
Cantor Global Healthcare Conference
Presenter: Chief Executive Officer Marty Duvall

Wednesday, October 3, 9:00 a.m. ET
Leerink Roundtable Series: Rare Disease & Oncology
Presenters: Chief Financial Officer Mark Foletta and Chief Medical Officer Asha Das, M.D.

Tuesday, October 9, 3:45 p.m. ET
Chardan Capital Markets 2nd Annual Genetic Medicines Conference
Presenter: Chief Executive Officer Marty Duvall

The live audio webcasts from the conferences and subsequent replay may be accessed by visiting the "Events & Presentations" page in the investors section of Tocagen’s website. The webcasts will be available shortly after conclusion of the presentation and archived on the company’s website for 90 days following the presentation.