On December 12, 2016 Atreca, Inc., a biotechnology company focused on developing novel therapeutics based on a deep understanding of the human immune response, reported positive preclinical findings generated using the Company’s Immune Repertoire Capture (IRC) technology, presented at the IBC Antibody Engineering & Therapeutics Conference being held in San Diego, California, December 11-15, 2016 (Press release, Atreca, DEC 12, 2016, View Source [SID1234522960]). In a presentation entitled "Analyzing B-cell Receptor Repertoires from Human Studies," Daniel Emerling, Ph.D., Atreca’s Senior Vice President, Research, provided a summary of key findings from the Company’s preclinical programs, including:
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Atreca’s IRC technology has identified and generated antibodies from active human immune responses, including antibodies from cancer patients who have responded well to immunotherapy and other treatments, patients with autoimmune disease, vaccinated subjects, and patients with infections.
Atreca’s immuno-oncology program is advancing antibodies that selectively bind tumor tissue types beyond that of the original patient and display potent antitumor activity in vivo.
Dr. Emerling stated, "Atreca’s IRC platform has demonstrated in preclinical disease models the power of mining a patient’s own anti-tumor immunity. In one of our applications of IRC, we generate natively paired antibody heavy and light chain sequences from blood plasmablasts – activated B cells – that are critical to the body’s own immune response to cancer and pathogens. As our programs progress, we anticipate being able to advance these promising biologic agents for potential use in cancer immunotherapy, vaccines, and diverse additional therapeutic applications."
"Over the past year, Atreca has made substantial progress both in advancing our internal and partnered programs and attracting world-class experts to our leadership team and advisory group," said Tito A. Serafini, Ph.D., Atreca’s President, Chief Executive Officer, and Co-Founder. "We will continue to advance multiple programs through preclinical studies to the clinic, with a primary focus on cancer immunotherapy applications of our novel and proprietary IRC platform."
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