On December 6, 2020 Arch Oncology, Inc., a clinical-stage immuno-oncology company focused on the discovery and development of anti-CD47 antibody therapies, reported the presentation of new preclinical data on AO-176 at the ASH (Free ASH Whitepaper) Annual Meeting 2020 (Press release, Arch Oncology, DEC 6, 2020, View Source;utm_medium=rss&utm_campaign=arch-oncology-presents-new-preclinical-data-on-highly-differentiated-anti-cd47-antibody-ao-176-at-ash-2020 [SID1234572225]). AO-176 is an anti-CD47 antibody with a potential best-in-class profile that works by blocking the "don’t eat me" signal and also by directly killing tumor cells, with preferential binding to tumor versus normal cells. Currently, AO-176 is being evaluated in Phase 1/2 clinical trials for the treatment of patients with select solid tumors and multiple myeloma, both as monotherapy and in combination with standard therapies.
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"At ASH (Free ASH Whitepaper) this year, we are pleased to highlight the growing body of preclinical data on AO-176, demonstrating a breadth of efficacy data in models of lymphoma, AML, and multiple myeloma," said Daniel Pereira, Ph.D., Chief Scientific Officer of Arch Oncology. "In our multiple myeloma preclinical studies, AO-176 shows potent tumor inhibition and complete durable responses as a monotherapy, as well as in combination with several standard therapies, including proteasome inhibitors, IMIDs, and anti-CD38 antibodies."
Poster Presentations at ASH (Free ASH Whitepaper) Annual Meeting & Exposition 2020
Date: December 5, 2020 7:00 am – 3:30 pm PT
Abstract Title: Pre-clinical Combination of AO-176, a Highly Differentiated Clinical Stage CD47 Antibody, with Either Azacitidine or Venetoclax Significantly Enhances DAMP Induction and Phagocytosis of Acute Myeloid Leukemia
Date: December 6, 2020 7:00 am – 3:30 pm PT
Abstract Title: AO-176, a Highly Differentiated Clinical Stage Anti-CD47 Antibody, Exerts Potent Anti-Tumor Activity in Preclinical Models of Multiple Myeloma as a Single Agent and in Combination With Approved Therapeutics
A copy of these poster presentations will be available at the beginning of each session at View Source
About AO-176
AO-176 is a humanized anti-CD47 IgG2 antibody with a potential best-in-class profile. AO-176 is highly differentiated, with the potential to improve upon the safety and efficacy profile relative to other agents in this class of innate checkpoint inhibitors. AO-176 works by blocking the "don’t eat me" signal, the standard mechanism of anti-CD47 antibodies. Beyond blocking this signal, AO-176 has additional mechanisms, including directly killing tumor cells and inducing DAMPs (Damage Associated Molecular Patterns), resulting in Immunogenic Cell Death. Importantly, AO-176 binds preferentially to tumor cells, instead of to normal cells, and binds even more potently to tumors in their acidic microenvironment (low pH). Publications and presentations on AO-176 can be found at View Source
AO-176 is being evaluated in Phase 1/2 clinical trials for the treatment of patients with select solid tumors and multiple myeloma, both as monotherapy and in combination with standard therapies. In a Phase 1 trial in solid tumors, AO-176 demonstrated encouraging safety and evidence of anti-tumor activity when administered as a single agent. Additional information about these trials may be found at www.clinicaltrials.gov using the trial identification number NCT03834948 (solid tumors) or NCT04445701 (multiple myeloma).