On June 12, 2023 Alpha Fusion reported the company has completed a third-party allotment of new shares to Toshiba Energy Systems & Solutions Corporation (hereinafter referred to as Toshiba ESS) as the second close of Series A (Press release, Alpha Fusion, JUN 12, 2023, View Source [SID1234647191]). This brings the total amount of funding raised to date to 590 million yen. Alpha Fusion will work with Toshiba ESS, which has strengths in fields such as nuclear power-related technology and heavy ion cancer therapy, to bring Japan’s world-leading innovative cancer treatment to the world as soon as possible. Building

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an astatine supply system both domestically and internationallyAlpha
Fusion is a startup that was established to deliver "targeted alpha nuclear medicine therapy using astatine (At-211)" to cancer patients around the world. Targeted alpha therapy (TAT) physically attacks cancer cells using alpha rays that emit high energy over a short distance of about a few cells. By binding alpha-particle-emitting nuclides to compounds (ligands) that accumulate in cancer cells, it is expected that cancer cells can be killed more safely and powerfully than the beta and gamma rays that are already in clinical use.

Astatine is a radioisotope that emits alpha rays and can be produced in an accelerator. Japanese research institutes such as Osaka University and the RIKEN Institute have led the world in astatine research. In order to build a stable supply system for astatine in Japan, which is expected to see an increase in demand in the future, Osaka University is leading the astatine manufacturing base construction project (J Innopla, a subsidy project for the Ministry of Economy, Trade and Industry’s "Development of an industry-academia fusion base at a regional core university"). In addition to Alpha Fusion, existing shareholder Sumitomo Heavy Industries, Ltd. and new shareholder Toshiba ESS are also participating in the construction of this astatine manufacturing base.