On April 22, 2024 Alltrna, a Flagship Pioneering company unlocking transfer RNA (tRNA) biology and pioneering tRNA therapeutics to regulate the protein universe and resolve disease, reported a poster presentation at the American Society of Gene & Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 27th Annual Meeting taking place May 7-11 in Baltimore and a talk and two poster presentations at TIDES USA 2024 taking place May 14-17 digitally and in-person in Boston (Press release, Alltrna, APR 22, 2024, View Source [SID1234646023]).
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Details of the presentations are as follows:
ASGCT 27th Annual Meeting
Poster Title: tRNA Therapeutics to Treat Stop Codon Disease
Session Date & Time: May 9, 12:00 PM to 7:00 PM ET
Presenter: Stephen Eichhorn, Ph.D., Head of Computational and Molecular Biology, Alltrna
Presentation Room: Exhibit Hall
Session Title: Oligonucleotide Therapeutics
Abstract Number: 1221
TIDES USA 2024
Talk Title: Manufacturing Strategies for Chemically Modified tRNAs
Session Date & Time: May 17, 5:00 PM to 5:30 PM ET
Presenter: William Kiesman, Ph.D., Chief Technology Officer, Alltrna
Session Title: Oligonucleotide Chemistry, Manufacturing, and Controls
Poster Title: Building 3-D homology models to support tRNA structure-based drug design
Presenter: Audrey Hughes, Ph.D., Scientist II, Computational Chemistry, Alltrna
Poster Title: Quantification of Tissue Delivery for tRNA Therapeutics in LNP Formulations
Presenter: W. George Lai, Ph.D., Head of DMPK, Drug Safety and Clinical Pharmacology, Alltrna
Posters will be displayed onsite in the exhibit hall throughout TIDES USA 2024.
About Stop Codon Disease
Stop Codon Disease encompasses thousands of rare and common diseases that stem from premature termination codons (PTC) also called nonsense mutations, where the code for an amino acid has been mutated into a premature "stop" codon. This results in a truncated or shortened protein product with no or altered biological activity that causes disease. Approximately 10% of all people with a genetic disease have Stop Codon Disease, representing approximately 30 million people worldwide. Alltrna is engineering tRNA medicines that can read these PTC mutations and deliver the desired amino acid, thereby restoring the production of the full-length protein.