On September 27, 2023 Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer, reported three preclinical poster presentations at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting November 1-5, 2023, in San Diego, CA (Press release, Allogene, SEP 27, 2023, View Source [SID1234635443]). These presentations will focus on the Company’s next generation AlloCAR T platform technologies and the foundation for an early-stage solid tumor product candidate, ALLO-182.

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"We are excited to share some of the groundbreaking work from our research team as we define next generation platform technologies that are designed to enhance engraftment and expansion of our AlloCAR TTM product candidates," said Zachary Roberts, M.D., Ph.D., Executive Vice President, Research & Development and Chief Medical Officer. "We believe this important and foundational work could expand the potential of off-the-shelf CAR T products by improving their persistence and anti-tumor activity across multiple targets while also creating a path to reducing the intensity of conditioning therapy."

Allogene Abstracts:

DAGGER PLATFORM TECHNOLOGY
Preclinical Evaluation of Allogeneic CD19 CAR T Cells Expressing an Anti-Rejection CD70 CAR
Presenter: Elvin Lauron, Ph.D.
Abstract: 279
Poster Session Display Date and Time: Friday, Nov. 3, 2023, 9:00 a.m. – 7:00 p.m. PT
Location: Exhibit Halls A and B1

CLOAK PLATFORM TECHNOLOGY
Generation of Immune-Evasive Allogeneic CAR T Cells by Inactivation of the HLA Transcriptional Regulator RFX5 and Disruption of the Immune Synapse
Presenter: Hsin-Yuan Cheng, Ph.D.
Abstract: 302
Poster Session Display Date and Time: Saturday, Nov. 4, 2023, 9:00 a.m. – 8:30 p.m. PT
Location: Exhibit Halls A and B1

SOLID TUMOR TARGET (ALLO-182)
Preclinical Development and Characterization of Allogeneic CAR T Cells Targeting Claudin18.2 Positive Tumors
Presenter: Joanne Li, Ph.D.
Abstract: 283
Poster Session Display Date and Time: Friday, Nov. 3, 2023, 9:00 a.m. – 7:00 p.m. PT
Location: Exhibit Halls A and B1