On August 21, 2019 Agenus Inc. (NASDAQ: AGEN), an immuno-oncology (I-O) company with a pipeline of immune checkpoint antibodies, adoptive cell therapies1 and cancer vaccines, reported a manufacturing agreement with Gilead for the supply of GS-1423, a bi-functional molecule licensed to Gilead (Press release, Agenus, AUG 21, 2019, View Source [SID1234538899]). This supply represents a second clinical batch for an ongoing Phase 1 clinical trial of GS-1423. Agenus is providing clinical supply at standard industry rates.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Our state-of-the-art facility in Berkeley, California and experienced staff have delivered more than 50 antibodies into the clinic2," said Al Dadson, Chief Manufacturing Officer of Agenus. "In the last 18-20 months, we have set path-breaking records with the development and manufacture of 8 compounds including two bi-specific compounds with 7 accepted INDs and one pending acceptance."

The collaboration between the two companies was announced in December 2018. Under the terms of the agreement, Agenus received $150 million in an upfront cash payment and equity investment and is eligible for approximately $1.7 billion in potential future fees and milestones.

GS-1423 is an investigational agent that has not been approved for any uses. Efficacy and safety have not been established.