On May 19, 2015 Advaxis reported it has entered into a non-exclusive research and clinical trial collaboration agreement with Sorrento Therapeutics to evaluate combinations of Advaxis’s Lm-LLO cancer immunotherapy technology platform, including ADXS-HPV, ADXS-PSA and ADXS-HER2, with Sorrento’s fully human antibodies targeting immune checkpoints, including GITR, OX40, LAG-3 and TIM-3 (Press release, Advaxis, MAY 19, 2015, View Source [SID:1234504592]). Sorrento has one of the largest and most diverse fully human antibody libraries in the industry designed to facilitate rapid identification and selection of highly specific therapeutic monoclonal antibody (mAb) product candidates. Schedule your 30 min Free 1stOncology Demo! Advaxis’s preclinical program for ADXS-HPV previously examined its therapeutic potential in combination with agonistic research antibodies, including anti-OX40 and anti-GITR. Preclinical data demonstrated that the combination of ADXS-HPV with agonistic research antibodies led to significant inhibition of tumor growth and prolonged survival in tumor-bearing mice. Complete regression of established tumors occurred in 40% and 60% of animals treated with ADXS-HPV in combination with anti-OX40 and anti-GITR antibodies, respectively (AACR Abstract #LB-229). Know more, wherever you are: "We welcome the collaboration with Sorrento to evaluate its immunomodulatory antibodies in combination with our Lm-LLO immunotherapy technology platform," said Daniel J. O’Connor, President and Chief Executive Officer of Advaxis. "Leveraging Sorrento’s fully human antibody library and Advaxis’s Lm-LLO immunotherapy technology offers a significant opportunity to target multiple cancer indications and extend the potential of our respective company’s technologies."
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Latest on Antibodies in Oncology, book your free 1stOncology demo here.
Under the terms of the agreement, Advaxis will conduct the studies and the companies will equally share the expenses. The companies hope to commence the first of the two planned combination studies in 2016. Results from the studies will be used to determine whether further clinical development of specific combinations is warranted.
"Clinical collaborations are an integral part of Sorrento’s strategy to accelerate the development of our diverse portfolio of immuno-oncology antibodies against a broad range of cancers," said Dr. Henry Ji, President and Chief Executive Officer at Sorrento. "We are encouraged by the data presented by Dr. Khleif at the AACR (Free AACR Whitepaper) Annual Meeting 2015, and believe there could be an important clinical benefit from the combination of our antibodies with Advaxis’s Lm-LLO immunotherapies."
Destum Partners acted as advisor to Advaxis for this collaboration agreement.