On April 8, 2022 Adaptimmune Therapeutics plc (Nasdaq: ADAP), a leader in cell therapy to treat cancer, reported data from the multinational, multicenter, screening protocol (NCT02636855) at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) annual meeting in a poster entitled "Identifying MAGE-A4-Positive Tumors for SPEAR T-Cell Therapies in HLA-A*02–Eligible Patients" (Press release, Adaptimmune, APR 8, 2022, View Source [SID1234611723]).
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"This large clinical dataset continues building the science around MAGE-A4 expression, and provides a broad, real-world understanding of patient eligibility for our clinical trials with SPEAR T-cell therapies targeting MAGE-A4," said Elliot Norry, Adaptimmune’s Chief Medical Officer. "This information confirms the potential of our MAGE-A4 franchise and our continued commitment to patients and clinicians."
The screening protocol prospectively evaluated HLA types and MAGE-A4 expression levels to determine eligibility for the Company’s clinical trials with SPEAR T-cells targeting MAGE-A4 across a broad range of solid tumors. To be eligible, patients are required to be HLA-A*02 positive1 and tumor samples need to meet protocol-defined MAGE-A4 expression levels2 . Data were collected for screening in the Phase 1 trial of afami-cel (formerly ADP-A2M4; closed to enrollment) as well as the ongoing Phase 1 SURPASS trial.
Results from this large dataset are consistent with data previously shared by the Company and support MAGE-A4 as an important cancer target within the tumor types currently included in ongoing clinical trials of afami-cel and ADP-A2M4CD8.
Across sites in the US, Canada, and Spain, a total of 6167 patients had their HLA-A type accurately determined and 2729 (44.3%) were eligible based on protocol-defined criteria. Among HLA-eligible patients, 1543 had tumor samples evaluable for MAGE-A4 with 313 (20%) meeting the requirements for MAGE-A4 expression.
The rate of eligible MAGE-A4 expression levels was highest in synovial sarcoma (67%) and ranged from 20% to 35% across the following solid tumor indications: squamous small cell lung (35%); bladder (32%), esophagogastric junction (26%), ovarian (24%), head and neck squamous cell (22%), and esophageal (21%) cancers.