On May 16, 2024 Spanios, a firm that created and leverages its unique 3D tumoroid platforms to validate solid tumor therapies reported a partnership with Accelerated Biosciences, a company that licenses its commercial-grade human trophoblast stem cell (hTSC) platform for drug discovery, therapeutic development, biomanufacturing, and toxicology testing (Press release, Accelerated Biosciences, MAY 16, 2024, View Source [SID1234643413]).

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The partnership combines Spanios’ proprietary COMPASS platforms and patient-derived tumoroid models with AccelBio’s hTSC platform to advance therapeutic design across solid tumor cancers.

Accelerated Bio’s hTSC platform serves as the starting material for this collaboration. hTSCs are the earliest form of pluripotent stem cells that are ethically sourced. These cells are highly plastic and immune-privileged, making them ideal for numerous medical and biotechnological applications. Among many other functions that the hTSCs can perform, effector cells derived from the hTSCs have been shown to be successful against many cancer cells.

Spanios’ tumoroid research expertise enhanced by its ability to rapidly recapitulate preclinical therapeutic performance ex vivo will play a key role in generating clinically relevant data for the hTSCs. "We are excited about the preliminary data supporting the NK-like behaviors of these cells," said Vivek Ravi, Spanios CEO. "This opens a huge opportunity for cell-based therapies where other forms have struggled, especially for Ovarian, Colorectal and other challenging cancers, and is the driving force for the partnership."

"We are excited to collaborate with Spanios to advance the research and development of effector cells derived from hTSCs," said Yuta Lee, CEO of Accelerated Bio. "Together, we believe that we can further demonstrate the versatility of the hTSC platform for the development of the next-generation precision medicine therapies," said Ravi.