On September 26, 2023 A-Alpha Bio (A-Alpha), a synthetic biology and machine learning company that measures and engineers protein-protein interactions, reported the expansion of their collaboration with Amgen’s Induced Proximity Platform to characterize interactions between ligases and molecular glue targets for protein degradation (Press release, A-Alpha Bio, SEP 26, 2023, View Source [SID1234636945]).
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As part of a research collaboration initiated in 2022 with Amgen, a leading biotechnology company, A-Alpha discovered several weakly interacting ligase-target pairs between a list of Amgen’s targets and A-Alpha’s proprietary library of E3 ubiquitin ligases. Following review of the results from the initial collaboration and additional work carried out by Amgen, A-Alpha and Amgen have agreed to an expanded collaboration. Under the expanded collaboration agreement, A-Alpha will further interrogate selected pairs to evaluate glueability and provide structural insights expected to enable rational design of molecular glue degraders. A-Alpha Bio will receive an upfront payment and will be eligible for milestones and a royalty on product sales resulting from licensed ligase-target pairs.
"Our work with Amgen over the past six months has been exciting and fruitful. We have enjoyed collaborating with an incredible industry-leading team on this major area of interest," said David Younger, CEO and Co-Founder of A-Alpha Bio. "We look forward to expanding our collaboration and moving into the validation of glueability and the generation of data to inform rational molecular glue discovery. Combining our technology and expertise with Amgen’s has the potential to generate high-impact therapeutics and advance our mission to improve human health."