On September 25, 2024 NuCana plc (NASDAQ: NCNA) reported the issuance of a new patent by the United States Patent and Trademark Office (USPTO) covering NUC-7738’s composition of matter (Press release, Nucana, SEP 25, 2024, https://ir.nucana.com/news-releases/news-release-details/nucana-announces-grant-composition-matter-patent-nuc-7738-united [SID1234646859]). This patent (US12,054,510) is expected to serve as a key component of the intellectual property protection for NUC-7738, which currently consists of over 80 issued patents worldwide. NUC-7738 is a novel anti-cancer agent currently in a Phase 2 clinical study in combination with pembrolizumab in PD-1 inhibitor resistant melanoma patients, for which NuCana presented encouraging data at the ESMO (Free ESMO Whitepaper) Congress 2024 earlier this month.
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Hugh S. Griffith, NuCana’s Founder and Chief Executive Officer said: "We welcome the USPTO’s decision to grant this important new patent, which further strengthens the intellectual property protection of NUC-7738. This patent issuance follows our recent data presentation at ESMO (Free ESMO Whitepaper) which supports NUC-7738’s novel mode of action and its ability to make previously resistant tumors sensitive to rechallenge with PD-1 inhibitors by targeting multiple aspects of the tumor microenvironment. The majority of these PD-1 inhibitor resistant metastatic melanoma patients achieved a progression free survival of more than 5 months with NUC-7738 plus pembrolizumab. These results are very encouraging as the median progression free survival in this patient population is 2-3 months with the current standard of care. We look forward to advancing the development of this promising new anti-cancer agent."