On June 7, 2017 Foundation Medicine (NASDAQ: FMI) reported a collaboration with the National Cancer Institute (NCI) and ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) for their precision medicine cancer trial, NCI-Molecular Analysis for Therapy Choice (NCI-MATCH or EAY131) (Press release, Foundation Medicine, JUN 7, 2017, View Source [SID1234519461]). This ongoing study is evaluating the benefit of genomically-guided treatments targeting specific alterations within a person’s tumor, regardless of cancer type. Foundation Medicine will notify physicians at the more than 1,100 clinical sites participating in NCI-MATCH when the comprehensive genomic profiling (CGP) assays they ordered to guide clinical care, FoundationOne or FoundationOne Heme, reveal findings that may make a patient eligible for one of several NCI-MATCH treatments. Schedule your 30 min Free 1stOncology Demo! The FoundationOne and FoundationOne Heme assays comprehensively interrogate hundreds of cancer-related genes in solid tumors, or hematologic cancers and advanced sarcomas, respectively, to identify genomic alterations that can help match a patient with a therapy that targets those alterations. Foundation Medicine and its CGP assays were selected for participation in NCI-MATCH based on the validation, reliability and accuracy of the assays, the ability to review a high volume of patient cases due to the mainstream use of FoundationOne and FoundationOne Heme in clinical care today, and the ability to provide assay results in a format that can be uploaded into MATCHbox, the trial’s informatics system that generates patient treatment assignment information for the trial’s panel of experts to review.
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"The NCI-MATCH trial is vital to learning more about the genomic basis of cancer biology and the best ways to improve cancer treatment for each individual patient," said Vincent Miller, M.D., chief medical officer at Foundation Medicine. "We believe this innovative trial design leveraging genomics to inform potential treatment modalities will become the standard for oncology clinical studies, particularly to identify signals of effectiveness that can be studied in larger, more definitive trials. We believe our collaboration will help the clinical sites participating in the trial to identify a larger number of patients who may be eligible to enroll for treatment."
Through this collaboration, Foundation Medicine will assist ECOG-ACRIN and the NCI in casting a wider net for patients that may be eligible for NCI-MATCH. Foundation Medicine will identify individuals whose tumors are profiled through standard clinical care with FoundationOne or FoundationOne Heme and are found to harbor genomic alterations being studied in NCI-MATCH, as determined by Foundation Medicine’s proprietary SmartTrials engine that allows for alteration-level specificity in matching patients to the trial. If the individual is identified at a site that is participating in the trial, Foundation Medicine’s SmartTrials outreach services will notify their treating physician that the patient may be eligible for enrollment into NCI-MATCH. The oncologist can take the information into consideration when discussing treatment options with his or her patients. Foundation Medicine initiated inclusion of NCI-MATCH in this outreach in May 2017.
About the NCI-MATCH Study
NCI-MATCH is a phase II precision medicine trial that seeks to determine the effectiveness of treatment that is directed by genomic profiling in patients with solid tumors, lymphomas, or myelomas that have progressed following all standard treatments expected to prolong overall survival or rare cancer types for which there is no standard treatment. The study attempts to demonstrate that matching certain drugs or drug combinations in adults whose tumors have specific gene abnormalities will effectively treat cancer, regardless of its type. Such discoveries could be eligible to move on to larger, more definitive trials.