On July 18, 2024 BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) ("BriaCell" or the "Company"), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, reported significantly higher PFS for its top responder patient in the Phase 2 study of BriaCell’s Bria-IMT regimen in combination with an immune checkpoint inhibitor in metastatic breast cancer (Press release, BriaCell Therapeutics, JUL 18, 2024, View Source [SID1234645084]). The patient remains alive and she continues to receive BriaCell’s treatment regimen.
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"We are extremely pleased with the unprecedented survival benefit in this very-difficult-to-treat patient," stated Dr. William V. Williams, BriaCell’s President and CEO. "This data represents a step forward in our efforts to build on our knowledge and successes to transform cancer care for patients. We expect to replicate this positive data in our ongoing Phase 3 study and bring relief to cancer patients whose medical needs remain unmet."
"Despite recent advances in cancer therapy, metastatic breast cancer remains an unmet medical need, as current treatments are limited by poor survival and harsh side effects," commented Dr. Giuseppe Del Priore, BriaCell’s Chief Medical Officer. "The Bria-IMT regimen produced a much longer than expected survival benefit in addition to its favorable safety and tolerability in this patient suggesting its potential as a therapeutic option for these cancer patients."
The patient had a large right orbital lesion (behind the right eye) and a right temporal lobe lesion (in the right side of the brain). The temporal lobe lesion is no longer detectable, while the orbital lesion has continued to shrink markedly (see figure showing resolution of proptosis post treatment (small arrows) with reduction in tumor indicated by the large arrows). In addition, her tumor markers (blood tests that correlate with the amount of tumor in the body) have markedly decreased from her pre-treatment levels.