On June 19, 2024 Theralase Technologies Inc. ("Theralase" or the "Company") (TSXV: TLT) (OTCQB: TLTFF), a clinical stage pharmaceutical company dedicated to the research and development of light and/or radiation activated small molecules and their formulations, intended for the safe and effective destruction of various cancers, bacteria and viruses, reported that it’s lead drug formulation, Rutherrin, has demonstrated an ability to provide a complete response in a Non-Small Cell Lung Cancer ("NSCLC") animal model (Press release, Theralase, JUN 19, 2024, View Source [SID1234644441]).

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Theralase recently press released its latest research, using a well-established Lewis Lung Cancer ("LLC1") orthotopic model, representing NSCLC. In this model, mouse lungs are implanted with lung cancer cells, inducing these mice to develop very aggressive, fast growing and metastatic lung tumors.

The mice were treated with x-ray radiation only as a control and x-ray activated Rutherrin as the active arm. The mice treated with x-ray activated Rutherrin demonstrated up to a 4-fold reduced tumor progression, based on Computerized Tomography ("CT") scan assessment of tumor volumes.

These results demonstrate that animals treated with a combination of Rutherrin and radiation therapy showed an increase in median survival from 26 to 35 days, versus radiation only. In scientific publications, mouse survival of 9 days has been equated to the equivalent of 1 year survival in humans, but more importantly, is that one animal treated with the x-ray activated Rutherrin (which had a positive lung tumor verified by CT scan) demonstrated a complete response and is now considered cancer free.

Dr. Arkady Mandel, M.D., Ph.D., D.Sc., Chief Scientific Officer of Theralase stated, "The latest preclinical research demonstrates the ability of x-ray activated Rutherrin to eradicate lung cancer in an animal model. This is initial research and through optimization, Theralase hopes to achieve a complete response in a much greater percentage of animals, but this initial data is extremely encouraging. As a result of this latest success, Theralase has committed to bringing this technology to market through the systematic research and development of this cutting-edge clinical therapy to safely and effectively destroy various cancers in patients. As a direct result, our list of cancer targets has increased from bladder cancer, which in the late stage of clinical development, to encompass brain cancer, lung cancer and various blood-based cancers, such as: leukemia, lymphoma and multiple myeloma."

Roger DuMoulin-White, B.E.Sc., P.Eng., Pro.Dir., President and Chief Executive Officer of Theralase stated, "This latest research symbolizes the significant progress Theralase has made over the last few years in the research and development of world-class systemic and targeted therapies for the treatment of various hard-to- treat cancers, such as: bladder cancer, brain and lung cancer. Pending sufficient capitalization and completion of a Good Laboratory Practice ("GLP") toxicology analysis for Rutherrin, Theralase plans to commence clinical studies for brain cancer, lung cancer and various blood-based cancers. If proven safe and effective in humans, Theralase hopes to change the paradigm of how patients diagnosed with cancer are treated in the future."

About Lung Cancer:

Lung cancer is the leading cause of cancer death worldwide. Most patients die of progressive metastatic disease despite aggressive local and systemic therapies. The survival rate for lung cancer depends on the type, stage and age of the patient, with the overall 5-year survival rate for all types of lung cancer about 26.6%. Lung cancer is histologically classified into two main types: Small Cell Lung Cancer ("SCLC"), which accounts for approximately 15% of the patients diagnosed with lung cancer and Non-Small Cell Lung Cancer ("NSCLC"), which accounts for approximately 85%.