On May 23, 2024 CatalYm reported that positive new follow-up results from its ongoing "GDFATHER" Phase 1/2a trial (GDF-15 Antibody-mediaTed Human Effector Cell Relocation Phase 1/2a) will be featured in an oral presentation at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting 2024 in Chicago (Press release, Catalym, MAY 23, 2024, View Source [SID1234643584]).
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The trial is evaluating CatalYm’s lead GDF-15 neutralizing antibody, visugromab, in combination with immune checkpoint inhibitor nivolumab in late- to last-line, anti-PD-1/PD-L1 relapsed/refractory patients. Visugromab is designed to neutralize the tumor-produced Growth Differentiation Factor-15 (GDF-15), a central mediator of immune resistance to cancer therapies. Early interim data of the study, which were previously presented at the ESMO (Free ESMO Whitepaper) Immuno-Oncology Congress 2023, demonstrated signs for potent and durable anti-tumor efficacy as well as an excellent tolerability and safety profile for visugromab in combination with nivolumab in advanced-stage/last-line non-small cell lung cancer (NSCLC) and urothelial cancer patients (UC). Now matured data for NSCLC, UC and novel data for hepatocellular cancer (HCC) will be presented.
The ASCO (Free ASCO Whitepaper) Annual Meeting will be held in Chicago, Illinois, from May 31 to June 4, 2024.
Oral Presentation Details:
Presentation Title: Effects of neutralization of tumor-derived immunosuppressant GDF-15 on anti-PD-1 activity in anti-PD-(L)1 relapsed/refractory non-squamous NSCLC, urothelial, and hepatocellular cancer
Presenter: Dr. Ignacio Melero Bermejo, MD | Clinica Universidad de Navarra
Session: Developmental Therapeutics-Immunotherapy
Session Date and Time: Sunday, June 2, 2024, from 11:30 AM – 1:00 PM CDT
Location: S406 | On Demand | McCormick Place
Abstract Number: 2513
The full abstract details can be accessed via View Source The company will provide further information and a summary of the data following the oral presentation at ASCO (Free ASCO Whitepaper).