On March 28, 2024 Caris Life Sciences(Caris), the leading next-generation AI TechBio company and precision medicine pioneer that is actively developing and delivering innovative solutions to revolutionize healthcare and improve the human condition using molecular science and AI, reported that the company and collaborators within the Caris Precision Oncology Alliance (POA) will collectively present 10 studies across eight tumor types at the 2024 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting on April 5-10, 2024, in San Diego, CA, at Booth Number 1105 (Press release, Caris Life Sciences, MAR 28, 2024, View Source [SID1234641593]). Caris President, David Spetzler, MS, PhD, MBA, will lead an AACR (Free AACR Whitepaper) Scientist ↔ Survivor Program Special Session titled, "Very Early Cancer Detection Assays: The Future or Fantasy," on Tuesday, April 9, from 1:00 – 1:45 PM.
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"We are proud of the collaborative abstracts accepted for presentation at AACR (Free AACR Whitepaper), demonstrating the value of Caris’ comprehensive molecular profiling and the large-scale collaboration between the growing number of POA sites," said Caris EVP and Chief Medical Officer George W. Sledge, Jr., MD. "The findings represent important observations, particularly the power of large clinicogenomic datasets to enable the identification of new biomarkers with clinical implications across diverse tumor types, including lung, breast and prostate cancer. Moreover, we are excited to present validation data demonstrating the analytical and clinical utility of our AI-enabled whole exome and whole transcriptome liquid biopsy platform, Caris Assure, in early diagnosis, therapy selection and minimal residual disease monitoring for patients with cancer."
"Caris enables clinicians to make the best individualized treatment choices for their patients, researchers to discover new targets and the biopharmaceutical industry to develop the next breakthrough medicines," said Caris President David Spetzler, MS, PhD, MBA. "The findings illustrate how our physicians, scientists and collaborators in the POA are leveraging real-world evidence from over 593,000 lifetime clinical cases, including over 482,000 with matched molecular data and outcomes in Caris’ unique AI-driven platform, to deepen our understanding of the mechanisms of cancer pathogenesis and improve outcomes of all patients affected by cancer."
Mini symposium presentations include:
Tissue-specific thresholds and microenvironment correlates of tumor mutation burden associated with immunotherapy benefit and prognosis in microsatellite stable cancers. (Abstract Number: 1213)
April 7, 4:35 – 4:50 PM PST
Comprehensive molecular and immunological characterization of early onset esophagogastric cancer. (Abstract Number: 3890)
April 8, 3:35 – 3:50 PM PST
Poster presentations include:
Modulation of the MSS and MSI colorectal cancer immune microenvironment with FOLFOX and FOLFIRI -/+ anti-PD-1 immunotherapy. (Poster Number: 1189/23)
April 7, 1:30 – 5:00 PM PST
AI-enabled whole exome & transcriptome liquid biopsy addressing MCED, MRD, and therapy selection on a single platform. (Poster Number: 2300/11)
April 8, 9:00 AM – 12:30 PM PST
Surfaceome and cancer testis antigen profiling of lung adenocarcinoma by large-scale transcriptomic analysis. (Poster Number: 3361/18)
April 8, 1:30 – 5:00 PM PST
Describing the molecular landscape of cervical cancer metastases: Implications for future therapeutic targets. (Poster Number: 3362/19)
April 8, 1:30 – 5:00 PM PST
Characterization of PDLIM2 in non-small cell lung cancer. (Poster Number: 5201/9)
April 9, 9:00 AM – 12:30 PM PST
The genomic, transcriptomic, and immunologic landscape of TEM8 (ANTXR1) in neuroendocrine neoplasms (NENs). (Poster Number: 6851/28)
April 10, 9:00 AM – 12:30 PM PST
PIM kinases alter the prostate tumor immune microenvironment. (Poster Number: 6875/19)
April 10, 9:00 AM – 12:30 PM PST
Comprehensive molecular and immune profiling of triple-negative invasive lobular carcinoma. (Poster Number: 7037/4)
April 10, 9:00 AM – 12:30 PM PST
Poster and abstract summaries highlighting the Caris research presented at AACR (Free AACR Whitepaper) 2024 will be available onsite at Caris’ Booth (# 1105). The full abstracts will be available on the Caris website beginning on April 6.
The AACR (Free AACR Whitepaper) Scientist ↔ Survivor Program (SSP) is a unique program designed to build bridges and unity among the leaders of the scientific, cancer survivor and patient advocacy communities worldwide. By strengthening communications and forging partnerships between these important communities in the cancer field, the program enhances efforts to accelerate progress in the fight against cancer. Dr. David Spetzler will lead a special interest session at AACR (Free AACR Whitepaper)’s SSP, highlighting the current and future states of very early cancer detection assays.
The POA includes 91 cancer centers, academic institutions, research consortia and healthcare systems, including 43 NCI-designated cancer centers, collaborating to advance precision oncology and biomarker-driven research. POA members work together to establish and optimize standards of care for molecular testing through innovative research focused on predictive and prognostic markers that improve the clinical outcomes for cancer patients.