On March 19, 2024 Adela, Inc., an innovator in blood testing for minimal residual disease monitoring and early cancer detection through a proprietary genome-wide methylome enrichment technology, reported data will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting from April 5-10, 2024 from its tissue-agnostic minimal residual disease (MRD) assay (Press release, Adela, MAR 19, 2024, View Source [SID1234641278]). These data demonstrate the feasibility of the assay for cfDNA cancer signal quantification and prognostic prediction in HPV-positive and HPV-negative head & neck cancers following treatment. Data will also be presented on the analytical performance of Adela’s platform.
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In addition, Daniel De Carvalho, Ph.D., Adela’s Chief Scientific Officer, has been selected to serve as Chair of the Plenary Session "Discovery Science in Early Cancer Biology and Interception". Dr. De Carvalho will also present in the session "New Liquid Biopsy Technologies for Detection and Characterization of Cancer".
Adela plans to commercialize its first product, a tissue agnostic test for minimal residual disease (MRD) monitoring, in 2025. The product will be based on Adela’s genome-wide methylome enrichment platform, which utilizes the company’s patented technology, cfMeDIP-seq, originally developed by Dr. De Carvalho at University Health Network’s Princess Margaret Cancer Centre, in collaboration with investigators at Sinai Health System. Adela’s technology efficiently captures extensive, biologically-relevant genomic information to maximize test performance and improve treatment decisions. It can be applied across the entire cancer care continuum and is initially being developed for MRD and multi-cancer early detection.
Presentation Details
Abstract # 2427: The development of a tissue-agnostic genome-wide methylome enrichment MRD assay for applications across the cancer care continuum for head and neck malignancies
Geoffrey Liu1
Mon Apr 8, 2024 9 am-12:30 pm PT
Section 40 Poster Board Number 23
Abstract # 5024: Analytical performance of a genome-wide methylome enrichment platform to detect minimal residual disease from plasma-derived cell-free DNA
Hestia Mellert2
Tues Apr 9, 2024 9am – 12:30pm PT
Section 40 Poster Board Number 11
Discovery Science in Early Cancer Biology and Interception
Dr. Daniel De Carvalho (Chair)
Sat April 6, 2024 4:15 PM PT
Hall GH
New Liquid Biopsy Technologies for Detection and Characterization of Cancer Dr. Daniel De Carvalho
Tues April 9, 2024 12:30 – 2:00 PM PT
Ballroom 20 CD