On March 11, 2024 Ribometrix, a biotechnology company developing small molecule therapeutics that modulate RNA biology, reported that it will present two posters with preclinical data highlighting advancements across two distinct modalities at the 2024 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting (Press release, Ribometrix, MAR 11, 2024, View Source [SID1234641022]).
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The posters will show in vivo anti-tumor efficacy of Ribometrix’s lead candidate targeting the RNA-binding protein eIF4E in combination with standard-of-care across multiple indications, and the Company’s discovery of small molecules that directly bind a complex RNA structure within the c-MYC mRNA in cells, and demonstrate a reduction in c-MYC protein levels.
These new data support the potential for Ribometrix’s RNA-modulating approach to enable drugging well-validated therapeutic targets, including eIF4E and c-MYC, that are currently intractable to traditional small molecule approaches.
Presentation Details:
Abstract Title: Development of novel eIF4E inhibitors to potently and selectively suppress tumor growth across multiple indications
Abstract: 682 / 28
Presenter: Matthew Friedersdorf, Ph.D., Associate Director, Translational Medicine at Ribometrix
Session: PO.ET09.05 – Novel Antitumor Agents 2
Date: Saturday, April 7, 2024
Time: 1:30pm – 5:00pm CT
Abstract Title: Leveraging an RNA-targeting platform for the discovery of cell-active c-MYC mRNA-binding small molecules
Abstract: 680 / 26
Presenter: Katie Warner, SVP of RNA Biology at Ribometrix
Session: PO.ET09.05 – Novel Antitumor Agents 2
Date: Saturday, April 7, 2024
Time: 1:30pm – 5:00pm CT
At the time of presentation, Ribometrix’s posters will be made available on the "Publications" page of the "News" section of its website.
About eIF4E
Eukaryotic translation initiation factor 4E (eIF4E) is a crucial regulatory component of mRNA translation. It selectively promotes pro-oncogenic protein synthesis in response to activation of multiple tumor signaling pathways. Many pro-oncogenic signaling pathways require eIF4E activity to promote tumor growth. Clinically, eIF4E activity is elevated in many kinds of tumor and it is typically associated with poor prognosis. Thus, targeting eIF4E has the potential to enhance anti-cancer activity when given in combination with standard-of-care. Additionally, eIF4E is also central to many resistance mechanisms, therefore eIF4E inhibition has the potential to overcome drug resistance and re-sensitize tumors to anti-cancer therapies. Ribometrix is developing eIF4E inhibitors as a promising therapeutic strategy to inhibit oncogene expression to enhance efficacy in combination with other therapies and overcome resistance to targeted anti-cancer therapies.
About c-MYC
c-MYC is a well-validated oncogene with broad anti-cancer potential, as c-MYC expression is dysregulated in more than 50% of cancers and a key regulator in nearly every aspect of the oncogenic process. c-MYC has remained intractable to traditional small molecule drug discovery, primarily due to its lack of a defined small molecule binding pocket. By targeting the c-MYC mRNA with small molecules, Ribometrix is bypassing the "undruggable" challenges to successfully reduce c-MYC protein levels and develop a novel anti-cancer therapeutic for c-MYC-driven cancers.