Glycotope and Evotec enter licensing agreement to combine Glycotope antibodies and Evotec’s immune cell engager platform

On December 11, 2023 Glycotope GmbH (Glycotope) reported that it has signed an agreement with Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) to combine Glycotope’s antibodies with Evotec’s immune cell engager platform for the development of next generation immune cell engaging bispecifics by Evotec (Press release, Glycotope, DEC 11, 2023, View Source [SID1234638420]).

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First generation immune cell engager (ICE) bispecifics have revolutionized liquid tumor therapy but have had limited success so far in solid tumors due to, among other factors, a high risk of off-target toxicity. The ability of Glycotope’s antibodies to target highly specific tumor-associated protein/carbohydrate combined glyco-epitopes (GlycoTargets) means that their combination with the Evotec platform has significant potential to develop next generation ICE bispecifics to address solid tumor indications.

"The applicability of Glycotope antibodies to many different tumor indications, combined with good tumor selectivity makes them ideal targeting moieties for our novel, proprietary immune cell engager platform," stated Dr Cord Dohrmann, Chief Scientific Officer of Evotec SE.

"We are excited about combining these two highly innovative technologies to explore the development of next generation immune cell engaging bispecifics in a range of potential indications, including solid tumors," said Henner Kollenberg, CEO, Glycotope.

"This strategic relationship significantly expands the possible areas of application for our antibodies, and we are delighted to have been able to forge this exciting partnership with Evotec. Combining the unrivaled specificity of our antibodies with Evotec’s ability to create best in class bispecifics provides us with an excellent opportunity to explore potentially life changing treatments for patients across a range of indications," commented Patrik Kehler, CSO, Glycotope.