On December 5, 2023 Appia Bio, Inc., a biotechnology company developing allogeneic chimeric antigen receptor (CAR)-engineered invariant natural killer T (CAR-NKT) cell therapies from hematopoietic stem cells (HSCs) for patients with cancer, reported that it will present preclinical data on API-192, a first-in-class CAR-NKT allogeneic cell therapy for the treatment of a broad array of B-cell mediated malignancies including non-Hodgkin lymphoma, one of the most common cancers in the U.S (Press release, Appia Bio, DEC 5, 2023, View Source [SID1234638178]).
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These data will be delivered in a poster presentation at the 65th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition being held December 9-12, 2023 in San Diego, CA.
Title: API-192, an Allogeneic CD19/20 CAR-NKT Product Derived from Cord Blood CD34+ HSPCs for the Treatment of B-cell Malignancies
Date: Monday, December 11, 2023, 6:00-8:00 PM PT
Number: 4801
Session: 703. Cellular Immunotherapies: Basic and Translational: Poster III
Location: San Diego Convention Center Halls G-H
Presenter: Lanny Gov, Ph.D., principal scientist, Appia Bio
API-192 is the first development candidate out of a 2021 collaboration and license agreement between Appia Bio and Kite, a Gilead Company. Under the terms of the agreement, Appia Bio is responsible for preclinical and early clinical research of HSC-derived CAR-NKT product candidates engineered with CARs provided by Kite. Kite is responsible for the later development, manufacturing, and commercialization of the product candidates identified through the collaboration. API-192 is currently undergoing investigational new drug (IND)-enabling studies.
"It has been a fantastic team effort to bring API-192 forward as our first development candidate out of our ACUA technology platform. Our research has benefited from the collaboration and support of our partner, Kite-Gilead, and the opportunity to benchmark to the gold standard set by their autologous cell therapy leadership," said JJ Kang, Ph.D., co-founder and chief executive officer of Appia Bio. "We are excited to share these data that support API-192 as a healthy donor derived next-generation allogeneic cell therapy in lymphoma and bring it to patients in the clinic."
About API-192
API-192 is a human cord blood CD34+ hematopoietic stem and progenitor cell-derived natural killer T (NKT) cell therapy product engineered to express dual chimeric antigen receptors (CARs) targeting two prevalent B-cell antigens, CD19 and CD20 and armored with soluble IL-15 for improved expansion and persistence. Using its proprietary Appia Cells Utilized for Allogeneic (ACUA) platform, Appia Bio can manufacture allogeneic API-192 cells resembling endogenous NKT cells from hematopoietic stem and progenitor cells (HSPCs) at high yield and with high purity without genetic editing or purification steps.