On November 30, 2023 Adela, Inc., an innovator in blood testing for minimal residual disease monitoring and early cancer detection through a proprietary genome-wide methylome approach, reported data demonstrating the feasibility of using its platform for cfDNA cancer signal quantification and prognostic prediction in early stage non-small cell lung cancer (NSCLC), during the Plenary Abstract Session at the 2023 Multidisciplinary Thoracic Cancers Symposium in New Orleans (Press release, Adela, NOV 30, 2023, View Source [SID1234638075]). In samples from patients with newly-diagnosed NSCLC, collected at Princess Margaret Cancer Centre at University Health Network, cancer signal from cfDNA was detected and quantified using Adela’s platform, and recurrence-free survival was compared between samples with high and low cfDNA cancer signal.

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"Significant progress is being made in the field of oncology to develop additional adjuvant treatment options for patients with early-stage NSCLC. To maximize the benefit of these novel therapies on patient outcomes, clinicians need additional tools to stratify patients with NSCLC based on their likelihood of relapsing," said Geoffrey Liu, MSc, MD, Senior Scientist, Princess Margaret Cancer Centre at University Health Network. "The genome-wide methylome platform has the potential to be a meaningful tool to help predict a patient’s likelihood of recurrence in NSCLC, if the results presented today demonstrating strong prognostic prediction are replicated in future studies that include post-treatment samples."

In individuals with newly diagnosed stage I-II NSCLC, cfDNA cancer signal was quantified in 41 pre-treatment samples with a median follow-up time of 55.8 months. Individuals with higher quantities of cfDNA cancer signal prior to treatment had a significantly worse recurrence-free survival [hazard ratio (HR) 2.70 (95% CI 1.26, 5.78), log-rank P = 0.008].

"These data build upon Adela’s existing body of evidence in Head & Neck Cancer and Renal Cell Carcinoma, demonstrating that our genome-wide methylome enrichment platform has strong prognostic prediction across multiple cancer types," said Anne-Renee Hartman, MD, Chief Medical Officer, Adela. "In NSCLC, acquiring a tumor tissue sample for patients is often not possible. Our tissue-agnostic blood test, in development for predicting outcomes and informing adjuvant treatment decisions following surgery, will increase accessibility of MRD testing for patients and clinicians."

Presentation Details

Prognostic Performance of a Genome-Wide Methylome Enrichment Platform in Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Presenter: Geoffrey Liu, MD, Princess Margaret Cancer Centre at University Health Network

Scientific Session Title: Plenary Abstract Session

Session Date/Time: Thursday, November 30, 1:30 – 3:00 pm CT