On August 30, 2023 Eucure (Beijing) Biopharma Co., Ltd. ("Eucure"), a wholly owned subsidiary of Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen"), reported that the company has entered into a technology transfer agreement with Syncromune, Inc. ("Syncromune"), a US-based clinical-stage biopharmaceutical company focused on the development of SYNC-T, a platform technology designed to synchronize in situ neoantigen T cell education and immunostimulation, for the development and clinical supply of certain compounds (Press release, Syncromune, AUG 30, 2023, View Source [SID1234637482]).
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This agreement is an expansion to the license agreement executed in 2022 where Biocytogen/Eucure licensed worldwide rights for YH002 (anti-OX40 antibody) and other active ingredients to Syncromune for the exclusive development and commercialization of intratumoral immunotherapy based on SYNC-T technology. Under the newly signed agreement, Syncromune will be granted an option right and upon option-exercise, Eucure will transfer technology to Syncromune for the manufacture of YH002 and other clinical-stage antibodies currently being evaluated for intratumoral immunotherapy based on SYNC-T technology. Under the newly signed agreement, Syncromune will pay Eucure an upfront fee and, upon option-exercise, Eucure is entitled to receive milestone fees.
Currently, Syncromune’s SYNC-T investigational therapy is being used in Phase 1 investigator initiated trials and has produced preliminary clinical data supporting further development of the candidates.
"We are pleased to expand what has been a fruitful collaboration, to date, with Syncromune," said Yuelei Shen, Ph.D., President and CEO of Biocytogen. "As we continue identifying novel therapeutic antibodies suitable for development into tumor vaccine and other modalities, we look forward to establishing more strategic partnerships to advance the field of immunotherapy."
"We are excited that SYNC-T has shown initial anti-tumor activity based on the preliminary Phase 1 clinical data," said Eamonn Hobbs, President and Chief Executive Officer of Syncromune. "We believe this technology transfer agreement may help accelerate our FDA IND filling process, and we are optimistic that our proprietary SYNC-T investigational therapy may have the potential to provide a treatment benefit to cancer patients."
About YH002
YH002 is a recombinant anti-OX40 humanized IgG1 agonistic antibody. The specificity, safety, and anti-cancer efficacy of YH002 have been evaluated in a comprehensive panel of pre-clinical studies. A first-in-human (FIH), multicenter, open-label, Phase 1 dose-escalation study is currently underway in Australia to evaluate the safety, tolerability, and pharmacokinetics and determine the MTD/RP2D of YH002 in adult subjects with advanced solid malignancies.
About SYNC-T
Syncromune is developing SYNC-T, a disruptive personalized in situ platform drug immunotherapy designed to educate T cells and stimulate the immune system to treat metastatic solid tumors where other therapies have failed. SYNC-T utilizes a combination approach of tumor activation and targeted delivery, aiming to synchronize the timing and location of tumor antigen release with the functional activation of immune cells. To achieve tumor activation, a portion of a target tumor is lysed to generate immunogenic cell death and the release of Damage Associated Molecular Patterns (DAMPs) and tumor antigens, changing the tumor microenvironment by creating an in situ vaccine. The second component of the platform, targeted delivery, involves the intratumoral infusion of a proprietary fixed-dose combination drug with 4 active ingredients into the lysed portion of the tumor. This is designed to activate the immune system and combat immune suppression, which may result in patient-specific T cell education. The expansion of anti-cancer specific T cells can enable the immune system to recognize and destroy cancer in the treated tumor as well as in metastases throughout the body.