On November 6, 2023 Orano Med, a pioneer in targeted alpha therapy, and 48Hour Discovery, a novel peptide discovery platform company, reported their strategic collaboration to advance cancer treatment through radioligand discovery and development (Press release, 48Hour Discovery, NOV 3, 2023, View Source;utm_medium=rss&utm_campaign=orano-med-and-48hour-discovery-to-develop-innovative-peptide-receptor-radionuclide-therapy-for-targeted-cancer-treatment [SID1234637006]). This partnership aims to harness the potent properties of lead-212 (212Pb), a rare alpha-emitting radioisotope, in conjunction with 48Hour Discovery’s innovative peptide discovery technology and expertise.
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Orano Med is advancing precision medicine in oncology by capitalizing on the unique properties of lead-212 and its proprietary platform to develop new radioligand therapies. Their commitment to innovation and therapeutic excellence aligns with 48Hour Discovery’s dedication to redefining drug discovery through novel peptides.
The core of the collaboration is the development of a novel peptide receptor radionuclide therapy (PRRT) capable of selectively targeting cancer cells with unparalleled precision. Lead-212, renowned for its potent alpha-emitting properties, holds the potential to deliver therapeutic payloads directly to cancer cells, minimizing collateral damage to healthy tissues. The expertise of Orano Med in harnessing the therapeutic potential of 212Pb, combined with 48Hour Discovery’s cutting-edge peptide design platform, is driving the development of novel cancer treatment modalities.
48Hour Discovery’s innovative platform has garnered significant attention for its transformative approach to peptide-based drug discovery. Their methodology, encompassing state-of-the-art phage display libraries, high-throughput screening, and chemical modifications, has enabled the identification of peptides with enhanced affinity, specificity, and therapeutic potential. The partnership with Orano Med opens doors to leverage this expertise in crafting peptides that will deliver highly cytotoxic 212Pb on cancer cells with unparalleled effectiveness.
"Uniting Orano Med’s expertise in targeted alpha therapy with 48Hour Discovery’s innovative approach to drug discovery creates a powerful synergy," says Julien Dodet, CEO at Orano Med. "We are excited about the potential to reshape the landscape of cancer therapy and deliver transformative treatments to patients."
Rick Finnegan, CEO of 48Hour Discovery, shares, "Our collaboration with Orano Med represents a testament to the value of cross-disciplinary partnerships. Together, we embark on a journey that can redefine the paradigms of cancer treatment, offering new hope to patients worldwide."