On November 1, 2023 BostonGene, a leading provider of AI-driven molecular and immune profiling solutions, reported the Company will present four posters at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 38th Annual Meeting taking place November 3-5, 2023 at the San Diego Convention Center in San Diego, CA (Press release, BostonGene, NOV 1, 2023, View Source [SID1234636681]). BostonGene will also exhibit at booth 639.
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BostonGene session details are below:
Abstract: 143
Title: Correlating RNA-Seq Detection and IHC Staining of Potential ADC Targets: HER3, TROP2, Nectin4 and aFLR
Date and time: Friday, November 3 | 12:00 PM – 1:30 PM and 5:10 PM – 6:40 PM
Location: Exhibit Hall B
Presenter: Alexander Bagaev, PhD, BostonGene
This study showed that the IHC results of five promising ADC targets (HER3, HER2, TROP2, Nectin4, and aFLR) correlated with their RNA sequencing (RNA-seq) gene expression values, highlighting the potential use of RNA-seq to detect ADC targets.
Research conducted in collaboration with The University of Texas MD Anderson Cancer Center
Abstract: 555
Title: Challenges in Predicting ICI Response in HPV+ HNSCC: Insights into the Tumor Microenvironment
Date and time: Friday, November 3 | 12:00 PM – 1:30 PM and 5:10 PM – 6:40 PM
Location: Exhibit Hall B
Presenter: Anastasia Nikitina, PhD, BostonGene
Transcriptomic analysis of human papillomavirus (HPV)+ head and neck squamous cell carcinomas (HNSCCs) revealed a disparity in underlying mechanisms of ICI response, particularly related to the tumor microenvironment (TME), between HPV- and HPV+ HNSCC patients. This study underscores the importance of considering a patient’s HPV status when assessing mechanisms associated with ICI response in HNSCC.
Research conducted in collaboration with Thomas Jefferson University
Abstract: 222-K
Title: Integrated immunoprofiling and RNA sequencing (RNA-seq) for anti-PD-1 response prediction in head and neck squamous cell carcinomas (HNSCC)
Date and time: Saturday, November 4 | 11:55 AM – 1:25 PM and 7:00 PM – 8:30 PM
Location: Exhibit Hall B
Presenter: Michael Goldberg, PhD, BostonGene
In this study, immunoprofiling of peripheral blood cells in combination with RNA-seq of tumor tissues identified novel predictors of anti-PD-1 response in HNSCC, suggesting the utility of this integrated approach as a tool to develop biologic predictors of ICI response that can lead to more effective personalized treatment options for cancer patients.
Research conducted in collaboration with Thomas Jefferson University
Abstract: 532
Title: A Cross-Cohort Examination of Factors Impacting Immunotherapy Survival in Non-Small Cell Lung Cancer (NSCLC)
Date and time: Saturday, November 4 | 11:55 AM – 1:25 PM and 7:00 PM – 8:30 PM
Location: Exhibit Hall B
Presenter: Nikita Kotlov, BostonGene
BostonGene’s transcriptome-based TME classification approach and proprietary cell deconvolution tool Kassandra were used to identify the TME subtypes and characterize the TME cell types of NSCLC patients treated with ICIs. The results showed that the TME subtypes and CD8+ T cell infiltration were associated with overall and progression-free survival, indicating their potential as predictive biomarkers for immunotherapy response.
Research conducted in collaboration with St Luke’s Cancer Institute
To learn more or to schedule a meeting with BostonGene during SITC (Free SITC Whitepaper), please contact Maria Proia at [email protected].