On September 27, 2023 XNK Therapeutics AB reported that two posters, regarding bladder cancer (BC) and acute myeloid leukemia (AML) respectively, was presented at the 20th Meeting of the Society for Natural Immunity (NK2023) in Oslo, Norway, in September (Press release, XNK Therapeutics, SEP 27, 2023, View Source [SID1234635483]).
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XNK Therapeutics participate at NK2023 in Oslo and present the latest research relating to the company’s leading natural killer (NK) cell therapies. Two abstracts have been accepted for presentation at the meeting.
The poster on BC shows the feasibility of expanding autologous NK cells from peripheral blood mononuclear cells (PBMCs) from BC patients. Cells were collected from patients both before and after chemotherapy treatment and the expansion and activation process was successful at both collection points demonstrating flexibility in timing for manufacturing. There were no significant differences in total cell yield, NK fraction or NK cell cytotoxicity against tumor cells between cultures started with PBMCs collected before or after chemotherapy treatment.
In AML, the study demonstrated that it was possible to expand and activate NK cells from PBMCs of AML patients of diverse cohorts (remission, newly diagnosed, relapsed/refractory). These NK cells expressed activating receptors and were able to degranulate in response to – and kill- two different leukemic cell lines.
The data have been generated in collaboration with XNK’s external partners, Anders Ullén and Fernanda Costa Svedman at the Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden, for the BC study, and Abhishek Maiti and Naval Daver at The University of Texas MD Anderson Cancer Center in Houston, Texas, USA, for the AML abstract.
NK2023 is the 20th annual meeting arranged by the Society of Natural Immunity and takes place in Oslo, Norway, on September 26-29, 2023. The meeting will attract more than 450 participants and is focused entirely on NK cells, with a preceding day entirely focused on the development of NK cell-based immunotherapies.
"Discussing our pipeline with the leading NK cell experts at NK2023 will help us refine our path forward, and as one of the leading companies in the field we are pleased to contribute to this important meeting" said Anna-Karin Maltais, CSO of XNK Therapeutics.