On September 27, 2023 Onchilles Pharma, a private biotech company developing new pan-cancer therapeutics that leverage a novel mechanism of action, reported the presentation of preclinical data for the N17350 program at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 38th Annual Meeting, to be held virtually and at the San Diego Convention Center from November 1-5, 2023 (Press release, Onchilles Pharma, SEP 27, 2023, View Source [SID1234635456]).
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N17350, is a first-in-class biologic therapeutic inspired by the immunobiology of neutrophils, with the potential to be effective against a wide range of cancer types. The company is targeting to start first-in-human clinical trials in skin cancers, head and neck cancer, and triple-negative breast cancer in 2024.
Presentation Details
Poster Title: N17350 combines selective cancer killing with adaptive immune activation to eradicate tumors
Abstract Number: 1344
Date and Time: Saturday, November 4, 9:00 a.m. to 8:30 p.m. PT
Location: San Diego Convention Center, Hall A and B1 or online at View Source
About N17350 and its Novel Mechanism of Action
First described in research published in Cell from the lab of Onchilles’ Co-Founder Lev Becker, human neutrophils release catalytically active neutrophil elastase (called ELANE), which selectively and potently kills cancer cells independent of their genetics and anatomical origin, mobilizes adaptive immunity, and avoids resistance mechanisms. The team at Onchilles translated this ground-breaking discovery into a proprietary set of molecules, including N17350, with the potential to treat a wide variety of tumor types with an optimal efficacy and safety profile.