On September 19, 2023 Repare Therapeutics Inc. ("Repare" or the "Company") (Nasdaq: RPTX), a leading clinical-stage precision oncology company, reported that it will present initial data from Module 1 and 2 of its ongoing Phase 1 MYTHIC clinical trial in a plenary session at the upcoming AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), being held October 11-15, 2023 in Boston, MA (Press release, Repare Therapeutics, SEP 19, 2023, View Source [SID1234635267]). In addition to this presentation, the Company will present multiple posters at the conference highlighting preclinical and clinical developments, including data from Module 4 of its Phase 1/2 TRESR clinical trial.

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Module 1 and 2 of the Phase 1 MYTHIC clinical trial are evaluating lunresertib (RP-6306), a first-in-class, oral PKMYT1 inhibitor alone and in combination with camonsertib (RP-3500/RG6526), a potent and selective oral inhibitor of ATR, while Module 4 of the Phase 1/2 TRESR trial is evaluating camonsertib in combination with gemcitabine, both in molecularly selected advanced solid tumors. Repare entered into a worldwide license and collaboration agreement with Roche for the development and commercialization of camonsertib.

Details for the plenary and poster presentations are as follows:

Title: MYTHIC: First-in-human (FIH) biomarker-driven phase I trial of PKMYT1 inhibitor lunresertib (lunre) alone and with ATR inhibitor camonsertib (cam) in solid tumors with CCNE1 amplification or deleterious alterations in FBXW7 or PPP2R1A
Presenter: Dr. Timothy A. Yap, The University of Texas MD Anderson Cancer Center, Houston, TX
Abstract number: 35396
Poster number: B156
Session: Plenary Session 4: New Drugs on the Horizon
Session date and time: Friday, October 13 | 9:40 a.m. – 11:45 a.m. ET
Session location: Level 3, Ballroom AB

Title: Ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in combination with low dose gemcitabine in patients with solid tumors with DNA damage response (DDR) aberrations: Preclinical and Phase 1b results
Presenter: Dr. Ezra Rosen, Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
Poster number: B045
Session: Poster Session B
Session date and time: Friday, October 13 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D

Title: Circulating tumor DNA (ctDNA) genomic and epigenomic profiling (GuardantINFINITY) for diagnosis of DNA damage repair (DDR) loss of function (LOF) and response monitoring in the TRESR and ATTACC trials
Presenter: Dr. Ezra Rosen, Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
Poster number: A123
Session: Poster Session A
Session date and time: Thursday, October 12 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D

Title: Retrospective baseline biomarker analyses in a first-in-human Phase 1 trial of the PKMYT1 inhibitor lunresertib (RP-6306) in pts with advanced solid tumors harboring CCNE1 amplification and/or deleterious alterations in FBXW7 or PPP2R1A.
Presenter: Elia Aguado-Fraile, Repare Therapeutics
Poster number: B169
Session: Poster Session B
Session date and time: Friday, October 13 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D

Title: Preclinical development of PKMYT1 and ATR inhibitor combinations
Presenter: Michael Zimmerman, Repare Therapeutics
Poster number: B057
Session: Poster Session B
Session date and time: Friday, October 13 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D

Title: Preclinical development of PKMYT1 and WEE1 inhibitor combinations
Presenter: David Gallo, Repare Therapeutics
Poster number: A023
Session: Poster Session A
Session date and time: Thursday, October 12 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D