On August 29, 2023 Erasca, Inc. (the Company) reported dosing of the first patient in the SEACRAFT-1 Phase 1b trial evaluating the Company’s pan-RAF inhibitor naporafenib in combination with the MEK inhibitor trametinib (MEKINIST) in patients with RAS Q61X solid tumors (Press release, Erasca, AUG 29, 2023, View Source [SID1234634744]). RAS Q61X solid tumors affect over 150,000 patients in the United States and Europe. The Company expects to share signal-seeking efficacy data in relevant tumor types from SEACRAFT-1 between the second and fourth quarters of 2024. In addition, the Company is on track to initiate SEACRAFT-2, a pivotal Phase 3 trial to evaluate naporafenib plus trametinib in patients with NRAS-mutant melanoma, in the first half of 2024.

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