On August 24, 2023 Aptose Biosciences Inc. ("Aptose" or the "Company") (NASDAQ: APTO, TSX: APS), a clinical-stage precision oncology company developing highly differentiated oral kinase inhibitors to treat hematologic malignancies, reported that the Aptose management team will participate in the H.C. Wainwright 25th Annual Global Investment Conference being held September 11-13, 2023, in New York City (Press release, Aptose Biosciences, AUG 24, 2023, View Source [SID1234634673]).
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Dr. William G. Rice, Chairman, President and CEO of Aptose, will deliver the Company presentation on Monday, September 11, 2023, at 2:00 p.m. ET, and with Mr. Fletcher Payne, CFO of Aptose, will be hosting one-on-one meetings during the conference. To schedule a one-on-one meeting with the Aptose management team, please contact your conference representative.
H.C. Wainwright 25th Annual Global Investment Conference
Date: Monday, September 11, 2023
Presentation Time: 2:00 p.m. ET
Format: Live Presentation, Webcast
Speaker: William G. Rice, PhD, Chairman, President and Chief Executive Officer
Webcast Link: Click here
Recent Clinical Data Highlight with Tuspetinib
Aptose provided a recent update from an ongoing APTIVATE Phase 1/2 clinical trial with the Company’s lead agent, tuspetinib, a once daily oral agent with a unique kinase targeting pattern being developed for the treatment of patients with relapsed/refractory (R/R) AML. As of August 1, 2023, fifteen (15) patients had been dosed with the tuspetinib/venetoclax (TUS/VEN) doublet, ten (10) had reached an efficacy evaluable stage, and five (5) of the ten evaluable patients had achieved early responses (composite Complete Response rate (CRc) includes any CR, CRh, CRi and CRp). Among the ten (10) evaluable patients, nine (9) had failed prior venetoclax treatment (Prior-VEN), representing an emerging population with severe unmet medical need. Four (4) of the nine (9) Prior-VEN failure patients had already achieved responses with TUS/VEN (44% CRc). Three (3) responses emerged among seven (7) of the evaluable patients with wildtype FLT3 (43% CRc), which accounts for approximately 70% of the AML population, yet there are few treatment options and little in development for the wildtype patient population. Additionally, two (2) of three (3) patients with mutated FLT3 (67%) achieved responses. Importantly, The TUS/VEN combination continues to be safe and well tolerated.
AML Subgroup CRc Responses
Evaluable (10) 50% (5 of 10)
Prior-VEN (9) 44% (4 of 9)
FLT3-WT (7) 43% (3 of 7)
FLT3-MUT (3) 67% (2 of 3)