On July 31, 2023 G1 Therapeutics, Inc. (Nasdaq: GTHX), a commercial-stage oncology company, reported the publication of real world outcomes data from published and new unpublished studies showing the potential of trilaciclib to reduce single and multilineage myelosuppressive events associated with chemotherapy, cytopenia-related healthcare utilization, and hospitalizations in adults being treated for extensive stage small cell lung cancer (ES-SCLC) (Press release, G1 Therapeutics, JUL 31, 2023, View Source [SID1234633541]). This review of real-world experience with trilaciclib was published in Advanced Therapy.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
"This review provides important evidence of the broad benefit of trilaciclib utilization among patients with ES-SCLC to support treatment decisions," said Dr. Jerome Goldschmidt, Medical Oncologist with the Blue Ridge Cancer Center in Blacksburg, VA and the U.S. Oncology Network and lead author of the study. "The findings add to the growing body of evidence supporting the benefits of trilaciclib that were demonstrated in the clinical trials that led to its approval. The effect of trilaciclib on reducing grade 3 and 4 myelosuppressive HAEs as well as dose reduction and treatment delay should translate into improved clinical outcomes and QoL among these patients. Moreover, potential reduction in cytopenia-related healthcare utilization and hospitalizations may alleviate overall burden of ES-SCLC on healthcare systems."
The publication, entitled, "Real-World Outcomes of Trilaciclib Among Patients with Extensive-Stage Small Cell Lung Cancer Receiving Chemotherapy," was the result of a comprehensive literature review and synthesized published and new unpublished real-world studies of trilaciclib-treated and comparable non-trilaciclib-treated patients with ES-SCLC. Outcomes were compared qualitatively between the trilaciclib and historical non-trilaciclib reference groups, and between first line trilaciclib initiators and the overall trilaciclib population.
Existing real-world studies in ES-SCLC consistently demonstrate that trilaciclib-treated patients had numerically lower prevalence of single and multilineage grade ≥ 3 myelosuppressive HAEs and lower cytopenia-related healthcare utilization, in reference to comparable historical non-trilaciclib cohorts. The real-world outcomes associated with trilaciclib are consistent with clinical trials, despite a higher proportion of elderly population, poorer performance status, and variation in timing of initiation of trilaciclib in real-world studies.
In all trilaciclib cohorts, the weighted average prevalence of grade ≥ 3 myelosuppressive HAEs in ≥ 1 lineage, ≥ 2 lineages, and all three lineages was 40.5%, 14.5%, and 7.5%, respectively. All rates were numerically lower compared to the historical non-trilaciclib cohorts (58.8%, 28.0%, 13.0% respectively).
Cytopenia-related healthcare utilization was lower in the trilaciclib cohorts. Trilaciclib patients also had numerically fewer all-cause hospitalizations and shorter length of stay in reference to the historical non-trilaciclib patients.
In general, first-line trilaciclib initiators had numerically even lower myelosuppressive HAEs (grade ≥ 3 myelosuppressive HAEs in ≥ 1, ≥ 2, and all three lineages was 33.5%, 6.0%, and 5.5%, respectively) and also lower cytopenia-related healthcare utilization than the overall trilaciclib patients.
Dose reduction and treatment delay were also evaluated in certain of the reviewed studies. Lower average rates of dose reduction and treatment delays were observed among patients receiving trilaciclib in reference to the historical non-trilaciclib cohorts.
The publication can be found on the G1 website here.
About Small Cell Lung Cancer
In the United States, approximately 30,000 small cell lung cancer patients are treated annually. SCLC, one of the two main types of lung cancer, accounts for approximately 14% of all lung cancers. SCLC is an aggressive disease and tends to grow and spread faster than NSCLC. It is usually asymptomatic; once symptoms do appear, it often indicates that the cancer has spread to other parts of the body. About 70% of people with SCLC will have cancer that has metastasized at the time they are diagnosed. The severity of symptoms usually increases with increased cancer growth and spread. From the time of diagnosis, the general 5-year survival rate for people with SCLC is 6%. The five-year survival rates for limited-stage (the cancer is confined to one side of the chest) SCLC is 12% to 15%, and for extensive stage (cancer has spread to the other lung and beyond), survival rates are less than 2%. Chemotherapy is the most common treatment for ES-SCLC.